Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites

被引：120

作者：

Bogaert, Debby ^{[1
,2
]}

van Beveren, Gina J. ^{[1
,3
]}

de Koff, Emma M. ^{[1
,3
]}

Parga, Paula Lusarreta ^{[2
]}

Lopez, Carlos E. Balcazar ^{[2
]}

Koppensteiner, Lilian ^{[2
]}

Clerc, Melanie ^{[2
,6
]}

Hasrat, Raiza ^{[1
,3
]}

Arp, Kayleigh ^{[1
,3
]}

Chu, Mei Ling J. N. ^{[1
,3
]}

Groot, Pieter C. M. de ^{[4
]}

Sanders, Elisabeth A. M. ^{[1
,3
]}

Houten, Marlies A. van ^{[5
]}

Piters, Wouter A. A. de Steenhuijsen ^{[1
,3
]}

机构：

[1] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Paediat Immunol & Infect Dis, NL-3584 EA Utrecht, Netherlands

[2] Univ Edinburgh, Queens Med Res Inst, Ctr Inflammat Res, Edinburgh EH16 4TJ, Scotland

[3] Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, NL-3721 MA Bilthoven, Netherlands

[4] Spaarne Gasthuis, Dept Obstet & Gynaecol, NL-2035 RC Haarlem, Netherlands

[5] Spaarne Gasthuis, Spaarne Gasthuis Acad, NL-2134 TM Hoofddorp, Netherlands

[6] Swiss Fed Inst Technol, Inst Microbiol, CH-8093 Zurich, Switzerland

来源：

CELL HOST & MICROBE | 2023年 / 31卷 / 03期

基金：

荷兰研究理事会;

关键词：

CESAREAN-BORN INFANTS; GUT; SHAPES; MODE; MATURATION; DYNAMICS; BACTERIA; HEALTH; MILK; LIFE;

D O I：

10.1016/j.chom.2023.01.018

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Early-life microbiota seeding and subsequent development is crucial to future health. Cesarean-section (CS) birth, as opposed to vaginal delivery, affects early mother-to-infant transmission of microbes. Here, we assess mother-to-infant microbiota seeding and early-life microbiota development across six maternal and four infant niches over the first 30 days of life in 120 mother-infant pairs. Across all infants, we estimate that on average 58.5% of the infant microbiota composition can be attributed to any of the maternal source communities. All maternal source communities seed multiple infant niches. We identify shared and niche -specific host/environmental factors shaping the infant microbiota. In CS-born infants, we report reduced seeding of infant fecal microbiota by maternal fecal microbes, whereas colonization with breastmilk micro -biota is increased when compared with vaginally born infants. Therefore, our data suggest auxiliary routes of mother-to-infant microbial seeding, which may compensate for one another, ensuring that essential microbes/microbial functions are transferred irrespective of disrupted transmission routes.

引用

页码：447 / +

页数：21

共 58 条

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