Enhanced absorption of prenylated cinnamic acid derivatives from Brazilian green propolis by turmeric in humans and rats

被引:2
作者
Yamaga, Masayuki [1 ]
Kawabe, Hiroshi [1 ]
Tani, Hiroko [1 ]
Yamaki, Ayanori [1 ]
机构
[1] Yamada Bee Co Inc, Inst Bee Prod & Hlth Sci, 194 Ichiba, Kagamino, Okayama 7080393, Japan
来源
FOOD SCIENCE & NUTRITION | 2024年 / 12卷 / 07期
关键词
artepillin C; Brazilian green propolis; breast cancer resistant protein; cinnamic acid derivatives; drupanin; turmeric; ALPHA-GLUCOSIDASE INHIBITORS; IN-VITRO; GLYCEMIC CONTROL; RICH EXTRACTS; ANTIOXIDANT; NARINGENIN; APIGENIN; DYSFUNCTION; METABOLISM; DISEASE;
D O I
10.1002/fsn3.4116
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Prenylated cinnamic acid derivatives are the bioactive components of Brazilian green propolis (BGP). The effect of other botanical components on the pharmacokinetic profiles of these derivatives remains relatively unexplored. In the present study, we investigated the influence of several herbal extracts (turmeric, ginkgo leaf, coffee fruit, soybean, and gotu kola) on the plasma concentrations of cinnamic acid derivatives after BGP consumption. When the herbal extracts were co-administered with BGP in the clinical study, the area under the curve (AUC) values of artepillin C and drupanin, the major BGP components in plasma, were significantly increased by 1.7- and 1.5-fold, respectively, compared to those after BGP administration alone. Among the herbal extracts administered to rats, turmeric extract increased the AUC. Furthermore, a bidirectional transport assay suggested that artepillin C and drupanin are substrates of breast cancer resistance protein (BCRP), a drug elimination transporter. These results suggest that curcumin-containing turmeric extract may increase the plasma concentrations of artepillin C and drupanin via BCRP. Our findings enabled us to estimate the food-herb and herb-herb interactions in vivo in foods and herbal medicines containing cinnamic acid derivatives and prenylated compounds. This study investigated the effects of several herbal extracts (turmeric, ginkgo leaf, coffee fruit, soybean, and gotu kola) on the plasma concentrations of cinnamic acid derivatives after Brazilian green propolis (BGP) ingestion. In the clinical study, the AUC of artepillin C, a major plasma component of BGP, was significantly increased by 1.7-fold after co-administration of the herbal extracts and BGP compared with the administration of BGP alone. Among the herbal extracts, turmeric increased the AUC of artepillin C in rats.image
引用
收藏
页码:4680 / 4691
页数:12
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