Liver transplantation for post-COVID-19 cholangiopathy: A case series

被引：1

作者：

Sambommatsu, Yuzuru ^{[1
]}

Mouch, Charles ^{[2
]}

Kulkarni, Anand V. ^{[3
]}

Bruno, David A. ^{[1
]}

Eslami, Mehdi ^{[1
]}

Imai, Daisuke ^{[1
]}

Lee, Seung Duk ^{[1
]}

Khan, Aamir A. ^{[1
]}

Sharma, Amit ^{[1
]}

Saeed, Muhammad ^{[1
]}

Cotterell, Adrian H. ^{[1
]}

Levy, Marlon F. ^{[1
]}

Morales, Megan K. ^{[4
]}

Montenovo, Martin I. ^{[2
]}

Rao, Padaki N. ^{[3
]}

Reddy, Raghuram

Menon, Balachandran ^{[5
]}

Kumaran, Vinay ^{[1
,6
]}

机构：

[1] Virginia Commonwealth Univ, Hume Lee Transplant Ctr, Dept Surg, Sch Med,Div Transplant Surg, Richmond, VA USA

[2] Vanderbilt Univ, Med Ctr, Dept Surg, Div Hepatobiliary Surg & Liver Transplantat, Nashville, TN USA

[3] Asian Inst Gastroenterol, Dept Hepatol, Hyderabad, India

[4] Virginia Commonwealth Univ, Hume Lee Transplant Ctr, Sch Med, Dept Internal Med,Div Infect Dis, Richmond, VA USA

[5] Asian Inst Gastroenterol, Dept Liver Transplantat & Hepatobiliary Surg, Hyderabad, India

[6] Virginia Commonwealth Univ, Hume Lee Transplant Ctr, Sch Med, Dept Surg,Div Transplant Surg, West Hosp 15 th Floor, North Wing,1200 E Broad St, Richmond, VA 23298 USA

来源：

CLINICAL TRANSPLANTATION | 2023年 / 37卷 / 12期

关键词：

coronavirus; COVID-19; liver transplantation; SARS-CoV-2; SECONDARY SCLEROSING CHOLANGITIS; CRITICALLY-ILL PATIENTS;

D O I：

10.1111/ctr.15141

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

BackgroundPost-COVID-19 cholangiopathy is an emerging cholestatic liver disease observed in patients recovering from severe COVID-19 infection. Its prognosis is poor, necessitating liver transplantation in some cases. This study aimed to investigate the outcomes of liver transplantation for post-COVID-19 cholangiopathy.MethodsSeven patients who underwent liver transplantation for post-COVID-19 cholangiopathy at three institutions between 2020 and 2022 were included in this retrospective multi-center case series.ResultsAt the time of initial COVID-19 infection, all patients developed acute respiratory distress syndrome, and six patients (86%) required ICU admission. Median time intervals from the initial COVID-19 diagnosis to the diagnosis of post-COVID-19 cholangiopathy and liver transplantation were 4 and 12 months, respectively. Four patients underwent living donor liver transplantation, and three patients underwent deceased donor liver transplantation. The median MELD score was 22 (range, 10-38). No significant intraoperative complications were observed. The median ICU and hospital stays were 2.5 and 12.5 days, respectively. One patient died due to respiratory failure 5 months after liver transplantation. Currently, the patient and graft survival rate is 86% at a median follow-up of 11 months.ConclusionsLiver transplantation is a viable option for patients with post-COVID-19 cholangiopathy with acceptable outcome. Timely identification of this disease and appropriate management, including evaluation for liver transplantation, are essential.

引用

页数：8

共 28 条

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