Lenalidomide Augments Differentiation of Cultured Hair Follicle Derived Melanocyte Stem Cells Into Functional Melanocytes

被引：2

作者：

Kumari, Uma ^{[1
]}

Pervaiz, Naveed ^{[1
]}

Kaur, Harjot ^{[1
]}

Sharma, Himani ^{[1
]}

Parsad, Davinder ^{[2
]}

Kumar, Ravinder ^{[1
,3
]}

机构：

[1] Panjab Univ, Dept Zool, Chandigarh, India

[2] Postgrad Inst Med Educ & Res, Dept Dermatol, Chandigarh, India

[3] Panjab Univ, Dept Zool, Chandigarh 160014, India

来源：

DERMATOLOGY PRACTICAL & CONCEPTUAL | 2023年 / 13卷 / 02期

关键词：

lenalidomide; melanocyte stem cells; melanocyte; differentiation; TRANSCRIPTION FACTOR; VITILIGO; PROLIFERATION; REPIGMENTATION; EXPRESSION; MIGRATION;

D O I：

10.5826/dpc.1302a77

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Introduction: Melanocyte progenitors are embryonically derived from the neural crest and subsequently get localized in hair follicles and epidermis to provide hair and skin pigmentation. These progenitor cells in hair follicles repeatedly proliferate and differentiate to maintain pigmentation. Vitiligo, a pigmentary disorder, is associated with loss of melanocytes. Repigmentation of vitiligo lesions mainly depends upon the proliferation, migration and differentiation of melanocyte stem cells (MelSCs) into functional melanocytes. The current study is designed to check the efficacy of lenalidomide, an imide drug in the differentiation of MelSCs into functional melanocytes. Objectives:The aim of the study is to check the effect of lenalidomide in the proliferation, migration of cultured hair follicle derived melanocyte stem cells and their differentiation into functional melanocytes.

引用

页数：9

共 32 条

[1] Nascent blood vessels in the skin arise from nestin-expressing hair-follicle cells [J].