Cembrane diterpenoids: Chemistry and pharmacological activities

被引：11

作者：

Zhang, Na ^{[1
]}

Xu, Wei ^{[2
]}

Yan, Yushu ^{[1
]}

Chen, Mengjie ^{[1
]}

Li, Hua ^{[1
,2
]}

Chen, Lixia ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China

[2] Fujian Univ Tradit Chinese Med, Inst Struct Pharmacol & TCM Chem Biol, Coll Pharm, Fuzhou 350122, Peoples R China

来源：

PHYTOCHEMISTRY | 2023年 / 212卷

基金：

中国国家自然科学基金;

关键词：

Cembrane diterpenoids; Natural product; Pharmacological activities; SOFT CORAL-SARCOPHYTON; NF-KAPPA-B; GUM RESIN; BIOACTIVE CEMBRANOIDS; BOSWELLIA-CARTERII; ANTIINFLAMMATORY CEMBRANOIDS; LOBOPHYTUM-CRASSUM; A-C; PTP1B; TERPENOIDS;

D O I：

10.1016/j.phytochem.2023.113703

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cembrane diterpenoids (cembranoids), characterized by a 14-membered carbon ring and wide variety of functional groups, found in marine and terrestrial organisms. Many studies have shown that cembrane diterpenoids have cytotoxic and anti-inflammatory activities and are widely used in the development of new drugs. This review covered publications from 2011 to 2022 and classified the cembrane-type diterpenoids into isopropyl (ene) type, gamma-lactone or unsaturated five-membered ring, delta-lactone or unsaturated six-membered ring, epsilon-lactone or unsaturated seven-membered ring, and other cembrane diterpenes. In addition, the biological activity and structure-activity relationship were summarized. This will provide guidance for new cembrane-type diterpenes as lead compounds to explore their potential application for treating cancer and inflammatory diseases.

引用

页数：22

共 133 条

[1] OSMOTIC LOADING OF NEUTRALIZING ANTIBODIES DEMONSTRATES A ROLE FOR PROTEIN-TYROSINE-PHOSPHATASE 1B IN NEGATIVE REGULATION OF THE INSULIN ACTION PATHWAY
AHMAD, F
LI, PM
MEYEROVITCH, J
GOLDSTEIN, BJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (35) : 20503 - 20508
[2] Cembranoids from Boswellia species
Al-Harrasi, Ahmed
Avula, Satya Kumar
Csuk, Rene
Das, Biswanath
[J]. PHYTOCHEMISTRY, 2021, 191
[3] Distribution of the anti-inflammatory and anti-depressant compounds: Incensole and incensole acetate in genus Boswellia
Al-Harrasi, Ahmed
Csuk, Rene
Khan, Ajmal
Hussain, Javid
[J]. PHYTOCHEMISTRY, 2019, 161 : 28 - 40
[4] Marine natural products
Blunt, John W.
Copp, Brent R.
Keyzers, Robert A.
Munro, Murray H. G.
Prinsep, Michele R.
[J]. NATURAL PRODUCT REPORTS, 2012, 29 (02) : 144 - 222
[5] New flexible cembrane-type macrocyclic diterpenes as TNF-α inhibitors from the South China Sea soft coral Sarcophyton mililatensis
Bu, Qing
Yang, Min
Yan, Xian-Yun
Yao, Li-Gong
Guo, Yue-Wei
Liang, Lin-Fu
[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 222 : 880 - 886
[6] Mililatensols A-C, New Records of Sarsolenane and Capnosane Diterpenes from Soft Coral Sarcophyton mililatensis
Bu, Qing
Yang, Min
Yan, Xian-Yun
Li, Song-Wei
Ge, Zeng-Yue
Zhang, Ling
Yao, Li-Gong
Guo, Yue-Wei
Liang, Lin-Fu
[J]. MARINE DRUGS, 2022, 20 (09)
[7] Protein-tyrosine phosphatase-1B acts as a negative regulator of insulin signal transduction
Byon, JCH
Kusari, AB
Kusari, J
[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 1998, 182 (1-2) : 101 - 108
[8] Computationally Assisted Structural Elucidation of Cembranoids from the Soft Coral Sarcophyton tortuosum
Chao, Chih-Hua
Lin, Kuan-Hua
Huang, Chiung-Yao
Hwang, Tsong-Long
Dai, Chang-Feng
Huang, Hui-Chi
Sheu, Jyh-Horng
[J]. MARINE DRUGS, 2022, 20 (05)
[9] Cembranolides and Related Constituents from the Soft Coral Sarcophyton cinereum
Chao, Chih-Hua
Chen, Yi-Ju
Huang, Chiung-Yao
Chang, Fang-Rong
Dai, Chang-Feng
Sheu, Jyh-Horng
[J]. MOLECULES, 2022, 27 (06):
[10] Protein-tyrosine phosphatases PTP1B and Syp are modulators of insulin-stimulated translocation of GLUT4 in transfected rat adipose cells
Chen, H
Wertheimer, SJ
Lin, CH
Katz, SL
Amrein, KE
Burn, P
Quon, MJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (12) : 8026 - 8031

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