Diabetic Kidney Disease in Post-Transplant Diabetes Mellitus: Causes, Treatment and Outcomes

被引：6
作者：
Lim, Lee-Moay [1 ,2 ,3 ]
Chang, Jer-Ming [2 ,3 ]
Kuo, Hung-Tien [2 ,3 ]
机构：
[1] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 807, Taiwan
[2] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan
[3] Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung 807, Taiwan
来源：
BIOMEDICINES | 2023年 / 11卷 / 02期
关键词：
post-transplant diabetes mellitus; kidney transplantation; diabetic kidney disease; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; RENAL-TRANSPLANT RECIPIENTS; LIFE-STYLE INTERVENTION; BASAL INSULIN THERAPY; C VIRUS-INFECTION; VITAMIN-D; CALCINEURIN INHIBITOR; GLUCOSE-METABOLISM; GLYCEMIC CONTROL; UNITED-STATES;
D O I：
10.3390/biomedicines11020470
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Kidney transplant recipients are a unique subgroup of chronic kidney disease patients due to their single functioning kidney, immunosuppressive agent usage, and long-term complications related to transplantation. Post-transplant diabetes mellitus (PTDM) has a significant adverse effect on renal outcomes in particular. As transplantations enable people to live longer, cardiovascular morbidity and mortality become more prevalent, and PTDM is a key risk factor for these complications. Although PTDM results from similar risk factors to those of type 2 diabetes, the conditions differ in their pathophysiology and clinical features. Transplantation itself is a risk factor for diabetes due to chronic exposure to immunosuppressive agents. Considering current evidence, this article describes the risk factors, pathogenesis, diagnostic criteria, prevention strategies, and management of PTDM. The therapeutic options are discussed regarding their safety and potential drug-drug interactions with immunosuppressive agents.
引用
收藏
页数：15
相关论文
共 50 条
[31]   Leptin - A new marker for development of post-transplant diabetes mellitus? [J].
Dedinska, Ivana ;
Mackova, Nadada ;
Kantarova, Daniela ;
Kovacikova, Lea ;
Granak, Karol ;
Laca, Ludovit ;
Miklusica, Juraj ;
Skalova, Petra ;
Galajda, Peter ;
Mokan, Marian .
JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2018, 32 (09) :863-869
[32]   Post-Transplant Diabetes Mellitus: Is It Associated With Poor Allograft Outcomes in Renal Transplants? [J].
Choi, J. Y. ;
Kwon, O. J. .
TRANSPLANTATION PROCEEDINGS, 2013, 45 (08) :2892-2898
[33]   Post-transplant Diabetes Mellitus in Kidney Transplant Recipients in Sudan: A Comparison Between Tacrolimus and Cyclosporine-Based Immunosuppression [J].
Yousif, Elamein ;
Abdelwahab, Abdelrahman .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (02)
[34]   Increased cardiovascular risk profile and mortality in kidney allograft recipients with post-transplant diabetes mellitus in Spain [J].
Gonzalez-Posada, Jose Manuel ;
Hernandez, Domingo ;
Bayes Genis, Beatriz ;
Perez Tamajon, Lourdes ;
Garcia Perez, Javier ;
Maceira, Benito ;
Rivero Sanchez, Manuel ;
Seron, Daniel .
CLINICAL TRANSPLANTATION, 2006, 20 (05) :650-658
[35]   Leptin receptor gene polymorphisms in kidney transplant patients with post-transplant diabetes mellitus treated with tacrolimus [J].
Dziedziejko, Violetta ;
Safranow, Krzysztof ;
Kijko-Nowak, Miros Lawa ;
Malinowski, Damian ;
Domanski, Leszek ;
Pawlik, Andrzej .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 124
[36]   Genetic and Epigenetic Associations with Post-Transplant Diabetes Mellitus [J].
Abdelrahman, Zeinab ;
Maxwell, Alexander Peter ;
Mcknight, Amy Jayne .
GENES, 2024, 15 (04)
[37]   Post-transplant diabetes mellitus and preexisting liver disease-a bidirectional relationship affecting treatment and management [J].
Cigrovski Berkovic, Maja ;
Virovic-Jukic, Lucija ;
Bilic-Curcic, Ines ;
Mrzljak, Anna .
WORLD JOURNAL OF GASTROENTEROLOGY, 2020, 26 (21) :2740-2757
[38]   Post-transplant diabetes mellitus following heart transplantation [J].
Newman, Joshua D. ;
Schlendorf, Kelly H. ;
Cox, Zachary L. ;
Zalawadiya, Sandip K. ;
Powers, Alvin C. ;
Niswender, Kevin D. ;
Shah, Ravi V. ;
Lindenfeld, Joann .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2022, 41 (11) :1537-1546
[39]   Risk assessment and management of post-transplant diabetes mellitus [J].
Han, Eugene ;
Kim, Myoung Soo ;
Kim, Yu Seun ;
Kang, Eun Seok .
METABOLISM-CLINICAL AND EXPERIMENTAL, 2016, 65 (10) :1559-1569
[40]   Association of early post-transplant hyperglycaemia and diabetes mellitus on outcomes following heart transplantation [J].
Muir, Christopher A. ;
Kuang, William ;
Muthiah, Kavitha ;
Greenfield, Jerry R. ;
Raven, Lisa M. .
DIABETIC MEDICINE, 2025, 42 (01)
12345