Diabetic Kidney Disease in Post-Transplant Diabetes Mellitus: Causes, Treatment and Outcomes

被引：4
作者：
Lim, Lee-Moay [1 ,2 ,3 ]
Chang, Jer-Ming [2 ,3 ]
Kuo, Hung-Tien [2 ,3 ]
机构：
[1] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 807, Taiwan
[2] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan
[3] Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung 807, Taiwan
来源：
BIOMEDICINES | 2023年 / 11卷 / 02期
关键词：
post-transplant diabetes mellitus; kidney transplantation; diabetic kidney disease; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; RENAL-TRANSPLANT RECIPIENTS; LIFE-STYLE INTERVENTION; BASAL INSULIN THERAPY; C VIRUS-INFECTION; VITAMIN-D; CALCINEURIN INHIBITOR; GLUCOSE-METABOLISM; GLYCEMIC CONTROL; UNITED-STATES;
D O I：
10.3390/biomedicines11020470
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Kidney transplant recipients are a unique subgroup of chronic kidney disease patients due to their single functioning kidney, immunosuppressive agent usage, and long-term complications related to transplantation. Post-transplant diabetes mellitus (PTDM) has a significant adverse effect on renal outcomes in particular. As transplantations enable people to live longer, cardiovascular morbidity and mortality become more prevalent, and PTDM is a key risk factor for these complications. Although PTDM results from similar risk factors to those of type 2 diabetes, the conditions differ in their pathophysiology and clinical features. Transplantation itself is a risk factor for diabetes due to chronic exposure to immunosuppressive agents. Considering current evidence, this article describes the risk factors, pathogenesis, diagnostic criteria, prevention strategies, and management of PTDM. The therapeutic options are discussed regarding their safety and potential drug-drug interactions with immunosuppressive agents.
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页数：15
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