A New Fluorescent Probe for Hydrogen Sulfide Detection in Solution and Living Cells

被引：7

作者：

Feng, Wei ^{[1
,2
]}

Xiao, Qicai ^{[3
]}

Wang, Lu ^{[4
]}

Yang, Yuanyong ^{[1
]}

机构：

[1] Guizhou Med Univ, Sch Pharm, Guiyang 550025, Peoples R China

[2] BGI Shenzhen, Shenzhen 518038, Peoples R China

[3] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen 518107, Peoples R China

[4] Guizhou Med Univ, Coll Basic Med, Dept Physiol, Guiyang 550025, Peoples R China

来源：

MOLECULES | 2023年 / 28卷 / 17期

基金：

中国国家自然科学基金;

关键词：

hydrogen sulfide; fluorescent probe; H2S selective detection; H2S quantification; azide-reduction; PROTECTING GROUP; H2S; CHEMOSENSOR; INHIBITION; REDUCTION;

D O I：

10.3390/molecules28176195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since Hydrogen Sulfide (H2S) was recognized as a gas transmitter, its detection and quantification have become a hot research topic among chemists and biologists. In this area, fluorescent probes have shown great advantages: fast and strong response, low detection limit and easy manipulation. Here we developed a new fluorescent probe that detected H2S selectively among various bioactive and inorganic salts. This probe was based on the core structure of fluorescein and reacted with H2S through azide-reduction. Great linearity was achieved correlating fluorescence intensity and H2S concentrations in solution. The detection of H2S in cancer cells was also achieved.

引用

页数：9

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