Stem Cell-Derived Extracellular Vesicles for Cancer Therapy and Tissue Engineering Applications

被引:12
作者
Lee, Chung-Sung [1 ]
Lee, Min [2 ,3 ]
Na, Kun [4 ,5 ]
Hwang, Hee Sook [6 ]
机构
[1] Soonchunhyang Univ, Dept Pharmaceut Engn, Asan 31538, South Korea
[2] Univ Calif Los Angeles, Div Adv Prosthodont, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA
[4] Catholic Univ Korea, Dept Biomed Chem Engn, Bucheon 14662, South Korea
[5] Catholic Univ Korea, Dept Biotechnol, Bucheon 14662, South Korea
[6] Dankook Univ, Dept Pharmaceut Engn, Cheonan 31116, South Korea
基金
新加坡国家研究基金会;
关键词
Stem cells; extracellular vesicles; cell-freetherapy; cancer treatment; tissue engineering; MESENCHYMAL STROMAL CELLS; DRUG-DELIVERY SYSTEM; BONE-MARROW; POLYMERIC NANOPARTICLES; INTERNATIONAL-SOCIETY; LOADED EXOSOMES; ADIPOSE; DISEASE; DOXORUBICIN; REPAIR;
D O I
10.1021/acs.molpharmaceut.3c00376
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Recently, stem cells and their secretomes have attracted great attention in biomedical applications, particularly extracellular vesicles (EVs). EVs are secretomes of cells for cell-to-cell communication. They play a role as intercellular messengers as they carry proteins, nucleic acids, lipids, and therapeutic agents. They have also been utilized as drug-delivery vehicles due to their biocompatibility, low immunogenicity, stability, targetability, and engineerable properties. The therapeutic potential of EVs can be further enhanced by surface engineering and modification using functional molecules such as aptamers, peptides, and antibodies. As a consequence, EVs hold great promise as effective delivery vehicles for enhancing treatment efficacy while avoiding side effects. Among various cell types that secrete EVs, stem cells are ideal sources of EVs because stem cells have unique properties such as self-renewal and regenerative potential for transplantation into damaged tissues that can facilitate their regeneration. However, challenges such as immune rejection and ethical considerations remain significant hurdles. Stem cell-derived EVs have been extensively explored as a cell-free approach that bypasses many challenges associated with cell-based therapy in cancer therapy and tissue regeneration. In this review, we summarize and discuss the current knowledge of various types of stem cells as a source of EVs, their engineering, and applications of EVs, focusing on cancer therapy and tissue engineering.
引用
收藏
页码:5278 / 5311
页数:34
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