A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors

被引：7

作者：

Derar, Abeer Rashad ^{[1
]}

Ahmed, Neven ^{[1
]}

Hussien, Emad Mohamed ^{[1
]}

机构：

[1] Egyptian Drug Author EDA, 9 Abou Hazem Str,POB 29, Giza, Egypt

来源：

BMC CHEMISTRY | 2023年 / 17卷 / 01期

关键词：

Screen printed ion selective electrode; Au and Pt nanoparticles; All-solid-state electrode; Coated wire; Dipeptidyl peptidase-4 inhibitors; ION-SELECTIVE ELECTRODES; PERFORMANCE LIQUID-CHROMATOGRAPHY; DIPEPTIDYL PEPTIDASE-4 INHIBITORS; RP-HPLC METHOD; CARBON NANOTUBES; HUMAN PLASMA; SPECTROPHOTOMETRIC METHODS; METFORMIN; STABILITY; DAPAGLIFLOZIN;

D O I：

10.1186/s13065-023-00988-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report on the development of disposable screen printed carbon, nanostructure thin film Au/Pt and Pt/Pt all-solid state potentiometric sensors for some antidiabetic compounds called glibtins. The electrodes showed excellent calibration curves (1 x 10(-5)-1 x 10(-2) M) for alogliptin, saxagliptin and vildagliptin. The electrodes were fully characterized with respect to potential stability, dynamic response time, detection limit, effect of pH and interference according to the IUPAC recommendation. The proposed method is rapid and can be applied for the determination of gliptins at low cost with satisfactory precision (RSD & LE; 1%) and accuracy.

引用

页数：11

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