Skp2: A critical molecule for ubiquitination and its role in cancer

被引：18
作者：
Feng, Tianyang
Wang, Ping
Zhang, Xiling [1 ]
机构：
[1] China Med Univ, Affiliated Hosp 4, Dept Urol, Shenyang 110032, Peoples R China
来源：
LIFE SCIENCES | 2024年 / 338卷
关键词：
Ubiquitination; Skp2; Cancer; Cancer treatment; BOX PROTEIN SKP2; KINASE-ASSOCIATED PROTEIN-2; REGULATES AKT UBIQUITINATION; HUMAN PROSTATE-CANCER; CELL-CYCLE ARREST; S-PHASE; INHIBITOR P27(KIP1); DEPENDENT DEGRADATION; DOWN-REGULATION; HIPPO PATHWAY;
D O I：
10.1016/j.lfs.2023.122409
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The ubiquitin-proteasome system (UPS) is a multi-step process that serves as the primary pathway for protein degradation within cells. UPS activity also plays a crucial role in regulating various life processes, including the cell cycle, signal transduction, DNA repair, and others. The F-box protein Skp2, a crucial member of the UPS, plays a central role in the development of various diseases. Skp2 controls cancer cell growth and drug resistance by ubiquitinating modifications to a variety of proteins. This review emphasizes the multifaceted role of Skp2 in a wide range of cancers and the mechanisms involved, highlighting the potential of Skp2 as a therapeutic target in cancer. Additionally, we describe the impactful influence exerted by Skp2 in various other diseases beyond cancer.
引用
收藏
页数：14
相关论文
共 185 条
[1]   Ubiquitin chain diversity at a glance [J].
Akutsu, Masato ;
Dikic, Ivan ;
Bremm, Anja .
JOURNAL OF CELL SCIENCE, 2016, 129 (05) :875-880
[2]   CD28 costimulation mediates transcription of SKP2 and CKS1, the substrate recognition components of SCFSkp2 ubiquitin ligase that leads p27kip1 to degradation [J].
Appleman, Leonard J. ;
Chernova, Irene ;
Li, Lequn ;
Boussiotis, Vassiliki A. .
CELL CYCLE, 2006, 5 (18) :2123-2129
[3]   The history and future of targeting cyclin-dependent kinases in cancer therapy [J].
Asghar, Uzma ;
Witkiewicz, Agnieszka K. ;
Turner, Nicholas C. ;
Knudsen, Erik S. .
NATURE REVIEWS DRUG DISCOVERY, 2015, 14 (02) :130-146
[4]   FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis [J].
Barik, Ganesh Kumar ;
Sahay, Osheen ;
Mukhopadhyay, Anindya ;
Manne, Rajesh Kumar ;
Islam, Sehbanul ;
Roy, Anup ;
Nath, Somsubhra ;
Santra, Manas Kumar .
CELL DEATH & DISEASE, 2023, 14 (09)
[5]   Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase [J].
Bashir, T ;
Dorrello, NV ;
Amador, V ;
Guardavaccaro, D ;
Pagano, M .
NATURE, 2004, 428 (6979) :190-193
[6]   Exploring the Role of Ubiquitin-Proteasome System in Parkinson's Disease [J].
Behl, Tapan ;
Kumar, Sachin ;
Althafar, Ziyad M. ;
Sehgal, Aayush ;
Singh, Sukhbir ;
Sharma, Neelam ;
Badavath, Vishnu Nayak ;
Yadav, Shivam ;
Bhatia, Saurabh ;
Al-Harrasi, Ahmed ;
Almoshari, Yosif ;
Almikhlafi, Mohannad A. ;
Bungau, Simona .
MOLECULAR NEUROBIOLOGY, 2022, 59 (07) :4257-4273
[7]   Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer [J].
Ben-Izhak, O ;
Lahav-Baratz, S ;
Meretyk, S ;
Ben-Eliezer, S ;
Sabo, E ;
Dirnfeld, M ;
Cohen, S ;
Ciechanover, A .
JOURNAL OF UROLOGY, 2003, 170 (01) :241-245
[8]   Coordination of cell growth and division by the ubiquitin-proteasome system [J].
Benanti, Jennifer A. .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2012, 23 (05) :492-498
[9]   The HECT family of E3 ubiquitin ligases: Multiple players in cancer development [J].
Bernassola, Francesca ;
Karin, Michael ;
Ciechanover, Aaron ;
Melino, Gerry .
CANCER CELL, 2008, 14 (01) :10-21
[10]   Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase [J].
Bornstein, G ;
Bloom, J ;
Sitry-Shevah, D ;
Nakayama, K ;
Pagano, M ;
Hershko, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (28) :25752-25757
12345678910