A new phenylspirodrimane derivative from the deep-sea-derived fungus Stachybotrys chartarum FS705

被引：0
作者：
Wang, Shuo [1 ,2 ,3 ]
Li, Saini [3 ]
Chen, Yuchan [3 ]
Wang, Yanlin [4 ]
Liu, Zhaoming [3 ]
Zhang, Weimin [3 ]
Deng, Hong [1 ,2 ]
机构：
[1] Guangdong Pharmaceut Univ, Guangdong Prov Key Lab Adv Drug Delivery Syst, Guangzhou 510006, Guangdong, Peoples R China
[2] Guangdong Pharmaceut Univ, Guangdong Prov Engn Ctr Top Precise Drug Delivery, Guangzhou 510006, Guangdong, Peoples R China
[3] Guangdong Acad Sci, Inst Microbiol, State Key Lab Appl Microbiol Southern China, Guangdong Prov Key Lab Microbial Culture Collect &, Guangzhou 510070, Guangdong, Peoples R China
[4] Chinese Acad Sci, South China Sea Inst Oceanol, Innovat Acad South China Sea Ecol & Environm Engn, Key Lab Ocean & Marginal Sea Geol, Guangzhou 510301, Guangdong, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2025年 / 39卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Stachybotrys chartarum; deep-sea-derived fungus; phenylspirodrimane derivative; biological activities;
D O I：
10.1080/14786419.2024.2305197
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new phenylspirodrimane derivative named stachybotrysin A (1), together with four known analogues (2-5) were isolated and purified from the solid culture of the deep-sea-derived Stachybotrys chartarum FS705. Their structures were determined by comprehensive spectroscopic analysis and the absolute configuration was evaluated by theoretical ECD calculations. Compounds 1-5 were evaluated for their cytotoxic, antibacterial and a-glucosidase inhibitory activities. The results showed that compound 2 displayed mild cytotoxicity with IC50 values in the range of 8.88 -22.73 mu M against four human tumour cell lines, SF-268, MCF-7, HepG-2, and A549. Compound 1 showed strong a-glucosidase inhibitory activity with an IC50 value of 20.68 mu M. Compounds 4 and 5 exhibited weak antibacterial activity against Bacillus subtilis. [Graphical Abstract]
引用
收藏
页码：2580 / 2586
页数：7
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