Estrogen sulfotransferase and sulfatase in steroid homeostasis, metabolic disease, and cancer

被引：8

作者：

Wang, Jingyuan ^{[1
,2
]}

Feng, Ye ^{[1
,2
,3
]}

Liu, Brian ^{[1
,2
]}

Xie, Wen ^{[1
,2
,4
]}

机构：

[1] Univ Pittsburgh, Ctr Pharmacogenet, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA

[3] Zhejiang Univ, Affiliated Hosp 1, Dept Endocrinol & Metab Dis, Sch Med, Hangzhou 310003, Peoples R China

[4] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA

来源：

STEROIDS | 2024年 / 201卷

关键词：

Sulfotransferase; Steroid sulfatase; Steroid homeostasis; Hormone homeostasis; Metabolic disease; Cancer; X-LINKED ICHTHYOSIS; BREAST-CANCER; DEHYDROEPIANDROSTERONE DHEA; CYTOSOLIC SULFOTRANSFERASES; GENE-EXPRESSION; MESSENGER-RNA; MOUSE MODELS; PHASE-II; SULT1E1; LIVER;

D O I：

10.1016/j.steroids.2023.109335

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sulfation and desulfation of steroids are opposing processes that regulate the activation, metabolism, excretion, and storage of steroids, which account for steroid homeostasis. Steroid sulfation and desulfation are catalyzed by cytosolic sulfotransferase and steroid sulfatase, respectively. By modifying and regulating steroids, cytosolic sulfotransferase (SULT) and steroid sulfatase (STS) are also involved in the pathophysiology of steroid-related diseases, such as hormonal dysregulation, metabolic disease, and cancer. The estrogen sulfotransferase (EST, or SULT1E1) is a typical member of the steroid SULTs. This review is aimed to summarize the roles of SULT1E1 and STS in steroid homeostasis and steroid-related diseases.

引用

页数：8

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