Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b Infections in Wild Terrestrial Mammals, United States, 2022

被引：44

作者：

Elsmo, Elizabeth J. ^{[1
,2
,18
]}

Wunschmann, Arno ^{[3
]}

Beckmen, Kimberlee B. ^{[4
]}

Broughton-Neiswanger, Liam E. ^{[5
]}

Buckles, Elizabeth L. ^{[6
]}

Ellis, Jayne ^{[7
]}

Fitzgerald, Scott D. ^{[7
]}

Gerlach, Robert ^{[8
]}

Hawkins, Shawna ^{[1
]}

Ip, Hon S. ^{[9
]}

Lankton, Julia S. ^{[9
]}

Lemley, Erin M. ^{[1
,10
]}

Lenoch, Julianna B. ^{[11
]}

Killian, Mary L. ^{[12
]}

Lantz, Kristina ^{[12
]}

Long, Lindsey ^{[13
]}

Maes, Roger ^{[7
]}

Mainenti, Marta ^{[14
]}

Melotti, Julie ^{[15
]}

Moriarty, Megan E. ^{[15
]}

Nakagun, Shotaro ^{[6
]}

Ruden, Rachel M. ^{[14
,16
]}

Shearn-Bochsler, Valerie ^{[9
]}

Thompson, Danielle ^{[7
]}

Torchetti, Mia K. ^{[12
]}

Van Wettere, Arnaud J. ^{[17
]}

Wise, Annabel G. ^{[7
]}

Lim, Ailam L. ^{[1
,2
]}

机构：

[1] Univ Wisconsin Madison, Sch Vet Med, Madison, WI USA

[2] Wisconsin Vet Diagnost Lab, Madison, WI USA

[3] Minnesota Vet Diagnost Lab, St Paul, MN USA

[4] Alaska Dept Fish & Game, Fairbanks, AK USA

[5] Washington Anim Dis Diagnost Lab, Pullman, WA USA

[6] New York State Anim Hlth Diagnost Ctr, Ithaca, NY USA

[7] Michigan State Univ, Vet Diagnost Lab, Lansing, MI USA

[8] Alaska Dept Environm Conservat, Anchorage, AK USA

[9] Natl Wildlife Hlth Ctr, Madison, WI USA

[10] Dane Cty Humane Soc Wildlife Ctr, Madison, WI USA

[11] US Dept Agr Natl Wildlife Res Ctr, Ft Collins, CO USA

[12] USDA Anim & Plant Hlth Inspect Serv, Ames, IA USA

[13] Wisconsin Dept Nat Resources, Madison, WI USA

[14] Iowa State Univ Vet Diagnost Lab, Ames, IA USA

[15] Michigan Dept Nat Resources, Lansing, MI USA

[16] Iowa Dept Nat Resources, Ames, IA USA

[17] Utah Vet Diagnost Lab, Logan, UT USA

[18] Wisconsin Vet Diagnost Lab, 445 Easterday Ln, Madison, WI 53706 USA

来源：

EMERGING INFECTIOUS DISEASES | 2023年 / 29卷 / 12期

基金：

英国科研创新办公室;

关键词：

H5N1; INFLUENZA; RED FOXES; SUBTYPE; CATS;

D O I：

10.3201/eid2912.230464

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe the pathology of natural infection with highly pathogenic avian influenza A(H5N1) virus of Eurasian lineage Goose/Guangdong clade 2.3.4.4b in 67 wild terrestrial mammals throughout the United States during April 1-July 21, 2022. Affected mammals include 50 red foxes (Vulpes vulpes), 6 striped skunks (Mephitis mephitis), 4 raccoons (Procyon lotor), 2 bobcats (Lynx rufus), 2 Virginia opossums (Didelphis virginiana), 1 coyote (Canis latrans), 1 fisher (Pekania pennanti), and 1 gray fox (Urocyon cinereoargenteus). Infected mammals showed primarily neurologic signs. Necrotizing meningoencephalitis, interstitial pneumonia, and myocardial necrosis were the most common lesions; however, species variations in lesion distribution were observed. Genotype analysis of sequences from 48 animals indicates that these cases represent spillover infections from wild birds.

引用

页码：2451 / 2460

页数：10

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