Bioaccumulation, microbiome composition and immunity, and epigenetic signatures associated with exposure to spherical, fibrous, and fragmented microplastics in the mussel Mytilus galloprovincialis

被引:29
作者
Park, Kiyun [1 ]
Kim, Won-Seok [2 ]
Park, Ji Won [2 ]
Kim, Tae Hee [3 ]
Kwak, Ihn-Sil [1 ,2 ,4 ]
机构
[1] Chonnam Natl Univ, Fisheries Sci Inst, Yeosu 59626, South Korea
[2] Chonnam Natl Univ, Fac Marine Technol, Yeosu 550749, South Korea
[3] Korea Inst Ind Technol, Adv Text R&D Dept, Ansan 426171, South Korea
[4] Chonnam Natl Univ, Fac Marine Technol, Chungnam 550749, South Korea
基金
新加坡国家研究基金会;
关键词
Bivalve; Microplastic uptake; DNA methylation; Microbiota; Pollution; DNA METHYLATION; GENE; FUTURE; SEARCH;
D O I
10.1016/j.jhazmat.2023.132691
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Microplastic (MP) pollution has become a major global concern due to the widespread use and discharge of plastics into the environment. However, very few studies have assessed the potential variations in the toxicity of MPs according to their shape and size. Therefore, our study sought to identify the biotoxic effects of spherical, fiber-shaped, and fragment-shaped polyethylene terephthalate MPs of different sizes at different concentrations on the Mediterranean mussel Mytilus galloprovincialis. The survival rate after exposure to small-sized MPs was lower than that observed for the larger type MPs. Bioaccumulation of MPs was different depending on the exposure periods and MP shapes. Interestingly, the fiber-shaped MPs underwent morphological modifications in the mussel body upon uptake. MP exposure also increased the global DNA methylation levels (i.e., an epigenetic signature), expression of the microbiota immunity-related toll-like receptor gene, and alteration of the gut mi-crobial composition in the mussel. These findings indicated that MPs of different shapes and sizes at different concentrations can alter the bioaccumulation sensitivity of mussels according to the exposure periods, and the balance of gut immunity and epigenetic process. Furthermore, our results demonstrated that MPs of different shapes, particularly fiber types, can undergo morphological modification in mussel tissues, thus posing a hazardous threat.
引用
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页数:12
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