Metabolic reprogramming of three major nutrients in platinum-resistant ovarian cancer

被引：2
作者：
Yan, Jinbowen [1 ]
Xu, Fangzhi [2 ]
Zhou, Dan [1 ]
Zhang, Shuo [1 ]
Zhang, Bo [1 ]
Meng, Qingwei [1 ]
Lv, Qiubo [1 ]
机构：
[1] Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Dept Obstet & Gynecol,Natl Ctr Gerontol, Beijing, Peoples R China
[2] Chinese Acad Med Sci, Inst Geriatr Med, Key Lab Geriatr, Beijing Hosp,Natl Ctr Gerontol,Natl Hlth Commiss,B, Beijing, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词：
ovarian cancer; platinum resistance; metabolic reprogramming; glucose metabolism; lipid metabolism; amino acid metabolism; MOLECULAR-MECHANISMS; EXPRESSION; CELLS; ACID; CHEMORESISTANCE; CISPLATIN; PROLIFERATION; METASTASIS; HALLMARKS; CARCINOMA;
D O I：
10.3389/fonc.2023.1231460
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metabolic reprogramming is a phenomenon in which cancer cells alter their metabolic pathways to support their uncontrolled growth and survival. Platinum-based chemotherapy resistance is associated with changes in glucose metabolism, amino acid metabolism, fatty acid metabolism, and tricarboxylic acid cycle. These changes lead to the creation of metabolic intermediates that can provide precursors for the biosynthesis of cellular components and help maintain cellular energy homeostasis. This article reviews the research progress of the metabolic reprogramming mechanism of platinumbased chemotherapy resistance caused by three major nutrients in ovarian cancer.
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页数：8
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共 82 条
  • [1] Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted
    Ali, Reem
    Aouida, Mustapha
    Sulaiman, Abdallah Alhaj
    Madhusudan, Srinivasan
    Ramotar, Dindial
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (13)
  • [2] Armstrong Deborah K, 2022, J Natl Compr Canc Netw, V20, P972, DOI 10.6004/jnccn.2022.0047
  • [3] Integrative Systemic and Local Metabolomics with Impact on Survival in High-Grade Serous Ovarian Cancer
    Bachmayr-Heyda, Anna
    Aust, Stefanie
    Auer, Katharina
    Meier, Samuel M.
    Schmetterer, Klaus G.
    Dekan, Sabine
    Gerner, Christopher
    Pils, Dietmar
    [J]. CLINICAL CANCER RESEARCH, 2017, 23 (08) : 2081 - 2092
  • [4] Long term treatment of metformin impedes development of chemoresistance by regulating cancer stem cell differentiation through taurine generation in ovarian cancer cells
    Bishnu, Aniketh
    Sakpal, Asmita
    Ghosh, Nilanjana
    Choudhury, Priyanka
    Chaudhury, Koel
    Ray, Pritha
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2019, 107 : 116 - 127
  • [5] Metabolic pathways promoting cancer cell survival and growth
    Boroughs, Lindsey K.
    DeBerardinis, Ralph J.
    [J]. NATURE CELL BIOLOGY, 2015, 17 (04) : 351 - 359
  • [6] Cantuaria G, 2001, CANCER-AM CANCER SOC, V92, P1144, DOI 10.1002/1097-0142(20010901)92:5<1144::AID-CNCR1432>3.0.CO
  • [7] 2-T
  • [8] Links between cancer metabolism and cisplatin resistance
    Cocetta, Veronica
    Ragazzi, Eugenio
    Montopoli, Monica
    [J]. INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, 2020, 354 : 107 - 164
  • [9] Decreased Levels of GSH Are Associated with Platinum Resistance in High-Grade Serous Ovarian Cancer
    Criscuolo, Daniela
    Avolio, Rosario
    Parri, Matteo
    Romano, Simona
    Chiarugi, Paola
    Matassa, Danilo Swann
    Esposito, Franca
    [J]. ANTIOXIDANTS, 2022, 11 (08)
  • [10] Cholesterol Homeostasis Modulates Platinum Sensitivity in Human Ovarian Cancer
    Criscuolo, Daniela
    Avolio, Rosario
    Calice, Giovanni
    Laezza, Chiara
    Paladino, Simona
    Navarra, Giovanna
    Maddalena, Francesca
    Crispo, Fabiana
    Pagano, Cristina
    Bifulco, Maurizio
    Landriscina, Matteo
    Matassa, Danilo Swann
    Esposito, Franca
    [J]. CELLS, 2020, 9 (04)
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