Nasal allergen challenge (NAC): Practical aspects and applications from an EU/US perspective-a Work Group Report of the AAAAI Rhinitis, Rhinosinusitis and Ocular Allergy Committee

被引：21

作者：

Cho, Seong H. ^{[1
,2
]}

Nanda, Anil ^{[3
,4
]}

Keswani, Anjeni ^{[5
]}

Adinoff, Allen ^{[6
,7
]}

Baroody, Fuad M. ^{[8
]}

Bernstein, Jonathan A. ^{[9
]}

Gherasim, Alina ^{[10
]}

Han, Joseph K. ^{[11
,12
]}

Koepke, Jerald W. ^{[6
,7
]}

Ledford, Dennis K. ^{[1
,2
]}

Pepper, Amber N. ^{[1
,2
]}

Rondon, Carmen ^{[13
]}

Schiffman, Amy ^{[14
]}

Wagenmann, Martin ^{[15
]}

Campo, Paloma ^{[13
]}

机构：

[1] Univ S Florida, Morsani Coll Med, Dept Internal Med, Div Allergy & Immunol, Tampa, FL USA

[2] James Haley Vet Affairs Hosp, Tampa, FL USA

[3] Ctr Asthma & Allergy, Lewisville, CA USA

[4] Univ Texas Southwestern Med Ctr, Div Allergy & Immunol, Dallas, TX USA

[5] George Washington Univ, Sch Med & Hlth Sci, Div Allergy Immunol, Washington, DC USA

[6] Colorado Allergy & Asthma Ctr, Denver, CO USA

[7] Univ Colorado, Dept Med, Div Allergy & Immunol, Denver, CO USA

[8] Univ Chicago, Sect Otolaryngol Head & Neck Surg, Chicago, IL USA

[9] Univ Cincinnati, Div Rheumatol Allergy & Immunol, Dept Internal Med, Cincinnati, OH USA

[10] ALYATEC Environm Exposure Chamber, Strasbourg, France

[11] Eastern Virginia Med Sch, Div Rhinol & Endoscop Sinus Surg, Norfolk, VA 23501 USA

[12] Eastern Virginia Med Sch, Div Allergy, Dept Otolayrngol Head & Neck Surg, Norfolk, VA 23501 USA

[13] Hosp Reg Univ Malaga, Inst Invest Biomed Malaga IBIMA, Red Asma Reacc Adversas Farmacos & Alergia ARADyA, Allergy Unit, Malaga, Spain

[14] Allergy Asthma & Immunol Specialists, Boca Raton, FL USA

[15] Dusseldorf Univ Hosp, Dept Otorhinolaryngol, Dusseldorf, Germany

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2023年 / 151卷 / 05期

关键词：

Allergen; challenge; nasal; obstruction; symptoms; MEDIATOR RELEASE; PROVOCATION TEST; EARLY RESPONSE; IMMUNOTHERAPY; DIAGNOSIS; CHILDREN; EFFICACY; PTERONYSSINUS; PREVALENCE; INCREASES;

D O I：

10.1016/j.jaci.2023.02.014

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Nasal allergen challenge (NAC) is applied in a variety of settings (research centers, specialty clinics, and hospitals) as a useful diagnostic and research tool. NAC is indicated for diagnosis of seasonal and perennial allergic rhinitis, local allergic rhinitis, and occupational rhinitis; to design the composition of allergen immunotherapy in patients who are polysensitized; and to investigate the physio-pathological mechanisms of nasal diseases. NAC is currently a safe and reproducible technique, although it is time- and resource-consuming. NAC can be performed by a variety of methods, but the lack of a uniform technique for performing and recording the outcomes represents a challenge for those considering NAC as a clinical tool in the office. The availability of standardized allergens for NAC is also different in each country. The objective of this workgroup report is to review the current information about NAC, focusing on the practical aspects and application for diagnosis of difficult rhinitis phenotypes (eg, local allergic rhinitis, occupational rhinitis), taking into account the particular context of practice in the United States and the European Union.

引用

页码：1215 / +

页数：12

共 55 条

[21] Allergen provocation tests in respiratory research: building on 50 years of experience [J].