A meta-analysis of the accuracy of Xpert MTB/RIF in diagnosing intestinal tuberculosis

被引：1

作者：

Ding, Yuan-Lin ^{[1
,2
]}

Yan, Rui-Chao ^{[1
,2
]}

Chen, Hao-Kai ^{[2
,3
]}

Xu-Guang, Guo ^{[2
,3
,4
,5
,6
,7
]}

机构：

[1] Guangzhou Med Univ, King Med Sch, Dept Med Lab Sci, Lab Med, Guangzhou, Peoples R China

[2] Guangzhou Med Univ, Dept Clin Lab Med, Affiliated Hosp 3, Guangzhou, Peoples R China

[3] Guangzhou Med Univ, Dept Clin Med, Clin Sch 3, Guangzhou, Peoples R China

[4] Guangzhou Med Univ, Dept Med Imageol, Clin Sch 2, Guangzhou, Peoples R China

[5] Guangzhou Med Univ, Affiliated Hosp 3, Guangdong Prov Key Lab Major Obstet Dis, Guangzhou, Peoples R China

[6] Guangzhou Med Univ, Affiliated Hosp 3, Guangdong Higher Educ Inst, Key Lab Reprod & Genet, Guangzhou, Peoples R China

[7] Guangzhou Med Univ, King Med Sch, Guangzhou Key Lab Clin Rapid Diag & Early Warning, Lab Med, Guangzhou, Peoples R China

来源：

LABORATORY MEDICINE | 2024年 / 55卷 / 02期

关键词：

Xpert MTB; RIF; intestinal tuberculosis; meta-analysis; diagnostic; tuberculosis; Mycobacterium tuberculosis; ABDOMINAL TUBERCULOSIS; EXPERIENCE; DILEMMA; UK;

D O I：

10.1093/labmed/lmad072

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective A detection method with high efficiency and accuracy is urgently needed in clinical work. The purpose of our study was to determine the diagnostic accuracy of the Xpert MTB/RIF assay for intestinal tuberculosis (ITB). Methods We searched PubMed and 4 other databases from their establishment to July 19, 2022, for published essays of diagnostic performance in which Xpert MTB/RIF was used to test patients with clinically suspected ITB. An assessment of the quality of the selected literature was conducted using QUADAS-2. We built forest plots by MetaDiSc software. Results The pooled Xpert MTB/RIF sensitivity was 48%, and the specificity was 99%. Moreover, the positive likelihood ratio for ITB diagnosis was 21.61. The negative likelihood ratio was 0.54. There were substantial variations between the study estimates of sensitivity (I-2 = 87.6%) and specificity (I-2 = 82.4%). Conclusion Intestinal TB is detected with limited diagnostic sensitivity by Xpert MTB/RIF but with high specificity. An Xpert-positive result may facilitate the rapid identification of ITB cases. Nevertheless, a negative result has less certainty in excluding the disease.

引用

页码：238 / 244

页数：7

共 29 条

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