ADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer

被引：7

作者：

Hata, Nanako ^{[1
]}

Shigeyasu, Kunitoshi ^{[1
]}

Umeda, Yuzo ^{[1
]}

Yano, Shuya ^{[1
]}

Takeda, Sho ^{[1
]}

Yoshida, Kazuhiro ^{[1
]}

Fuji, Tomokazu ^{[1
]}

Yoshida, Ryuichi ^{[1
]}

Yasui, Kazuya ^{[1
]}

Umeda, Hibiki ^{[1
]}

Takahashi, Toshiaki ^{[1
]}

Kondo, Yoshitaka ^{[1
]}

Kishimoto, Hiroyuki ^{[1
]}

Mori, Yoshiko ^{[1
,2
]}

Teraishi, Fuminori ^{[1
]}

Yamamoto, Hideki ^{[3
]}

Michiue, Hiroyuki ^{[4
]}

Nakamura, Keiichiro ^{[5
]}

Tazawa, Hiroshi ^{[1
]}

Fujiwara, Toshiyoshi ^{[1
]}

机构：

[1] Okayama Univ, Dept Gastroenterol Surg, Grad Sch Med Dent & Pharmaceut Sci, 2-5-1 Shikata Cho, Kita Ku, Okayama 7008558, Japan

[2] Saitama Med Univ, Saitama Med Ctr, Dept Digest Tract & Gen Surg, Saitama, Japan

[3] Okayama Univ, Dept Clin Genom Med, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan

[4] Okayama Univ, Neutron Therapy Res Ctr, Okayama, Japan

[5] Okayama Univ, Dept Obstet & Gynecol, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

关键词：

D O I：

10.1038/s41598-023-29397-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adenosine-to-inosine RNA editing is a process mediated by adenosine deaminases that act on the RNA (ADAR) gene family. It has been discovered recently as an epigenetic modification dysregulated in human cancers. However, the clinical significance of RNA editing in patients with liver metastasis from colorectal cancer (CRC) remains unclear. The current study aimed to systematically and comprehensively investigate the significance of adenosine deaminase acting on RNA 1 (ADAR1) expression status in 83 liver metastatic tissue samples collected from 36 patients with CRC. The ADAR1 expression level was significantly elevated in liver metastatic tissue samples obtained from patients with right-sided, synchronous, or RAS mutant-type CRC. ADAR1-high liver metastasis was significantly correlated with remnant liver recurrence after hepatic metastasectomy. A high ADAR1 expression was a predictive factor of remnant liver recurrence (area under the curve = 0.72). Results showed that the ADAR1 expression level could be a clinically relevant predictive indicator of remnant liver recurrence. Patients with liver metastases who have a high ADAR1 expression requires adjuvant chemotherapy after hepatic metastasectomy.

引用

页数：10

共 16 条

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