MAFLD and NAFLD in the prediction of incident chronic kidney disease

被引：14

作者：

Kwon, So Yoon ^{[1
]}

Park, Jiyun ^{[2
]}

Park, So Hee ^{[1
]}

Lee, You-Bin ^{[1
]}

Kim, Gyuri ^{[1
]}

Hur, Kyu Yeon ^{[1
]}

Koh, Janghyun ^{[3
]}

Jee, Jae Hwan ^{[3
]}

Kim, Jae Hyeon ^{[1
]}

Kang, Mira ^{[3
,4
]}

Jin, Sang-Man ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Endocrinol & Metab,Sch Med, 81 Irwon Ro, Seoul 06351, South Korea

[2] CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Div Endocrine & Metab,Sch Med, 59 Yatap Ro, Seongnam 14396, South Korea

[3] Sungkyunkwan Univ, Dept Hlth Promot Ctr, Ctr Hlth Promot, Samsung Med Ctr,Sch Med, 81 Irwon Ro, Seoul 06351, South Korea

[4] Sungkyunkwan Univ, Dept Digital Hlth, SAIHST, Seoul, South Korea

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

关键词：

FATTY LIVER-DISEASE; METABOLIC SYNDROME; FIBROSIS; OBESITY;

D O I：

10.1038/s41598-023-27762-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Whether metabolic dysfunction-associated fatty liver disease (MAFLD) can replace nonalcoholic fatty liver disease (NAFLD) is under debate. This study evaluated which definition better predicted incident chronic kidney disease (CKD). This was a 5.3-year (range, 2.8-8.3) retrospective cohort study of 21,713 adults who underwent at least two serial health examinations. Cox analyses were used to compare the risk of incident CKD among non-fatty liver disease (FLD) without metabolic dysregulation (MD; reference), non-FLD with MD, MAFLD-only, NAFLD-only, or both-FLD groups. Non-FLD with MD group (hazard ratio [HR] 1.23, 95% confidence interval [CI] 1.00-1.53), both-FLD group (HR 1.50, 95% CI 1.19-1.89), and MAFLD-only group (HR 1.97, 95% CI 1.49-2.60), but not NAFLD-only group (HR 1.06, 95% CI 0.63-1.79) demonstrated an increased risk of CKD. The increased risk of CKD was significant in MAFLD subgroups with overweight/obesity (HR 2.94, 95% CI 1.91-4.55), diabetes (HR 2.20, 95% CI 1.67-2.90), MD only (HR 1.50, 95% CI 1.19-1.89), excessive alcohol consumption (HR 2.71, 95% CI 2.11-3.47), and viral hepatitis (HR 2.38, 95% CI 1.48-3.84). The switch from NAFLD to MAFLD criteria may identify a greater number of individuals at CKD risk. The association was also significant in MAFLD patients with excessive alcohol consumption or viral hepatitis.

引用

页数：9