Mesenchymal stem cell therapy for non-healing diabetic foot ulcer infection: New insight

被引:36
|
作者
Mahmoudvand, Golnaz [1 ]
Rouzbahani, Arian Karimi [1 ]
Razavi, Zahra Sadat [2 ]
Mahjoor, Mohamad [3 ]
Afkhami, Hamed [4 ,5 ]
机构
[1] Lorestan Univ Med Sci, Student Res Comm, USERN Off, Khorramabad, Iran
[2] Iran Univ Med Sci, Fac Med, Physiol Res Ctr, Tehran, Iran
[3] Iran Univ Med Sci, Fac Med, Dept Immunol, Tehran, Iran
[4] Semnan Univ Med Sci, Nervous Syst Stem Cells Res Ctr, Semnan, Iran
[5] Shahed Univ, Fac Med, Dept Med Microbiol, Tehran, Iran
关键词
diabetic foot; foot ulcer; wound healing; mesenchymal stem cell; multipotent stem cell; LOWER-EXTREMITY; MACROPHAGE POLARIZATION; HELICOBACTER-PYLORI; ANGIOGENESIS; HIF-1-ALPHA; SKIN; PERSPECTIVE; ACTIVATION; EXPRESSION; ISCHEMIA;
D O I
10.3389/fbioe.2023.1158484
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Diabetic foot ulcer (DFU) is considered the most catastrophic complication of diabetes mellitus (DM), leading to repeated hospitalizations, infection, gangrene, and finally amputation of the limb. In patients suffering from diabetes mellitus, the wound-healing process is impaired due to various factors such as endothelial dysfunction and synthesis of advanced glycation end-products, hence, conventional therapeutic interventions might not be effective. With increasing therapeutic applications of mesenchymal stem cells (MSCs) in recent years, their potential as a method for improving the wound-healing process has gained remarkable attention. In this field, mesenchymal stem cells exert their beneficial effects through immunomodulation, differentiation into the essential cells at the site of ulcers, and promoting angiogenesis, among others. In this article, we review cellular and molecular pathways through which mesenchymal stem cell therapy reinforces the healing process in non-healing Diabetic foot ulcers.
引用
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页数:10
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