Exercise benefits in cardiovascular diseases: from mechanisms to clinical implementation

被引：75

作者：

Valenzuela, Pedro L. ^{[1
,2
]}

Ruilope, Luis M. ^{[3
,4
]}

Santos-Lozano, Alejandro ^{[5
]}

Wilhelm, Matthias ^{[6
]}

Kraenkel, Nicolle ^{[7
,8
]}

Fiuza-Luces, Carmen ^{[1
]}

Lucia, Alejandro ^{[9
,10
]}

机构：

[1] Hosp 12 Octubre imas12, Phys Act & Hlth Res Grp PaHerg, Res Inst, 7 Planta,Bloque D,Ave Cordoba S-N, Madrid 28041, Spain

[2] Univ Alcala, Dept Syst Biol, Madrid 28871, Spain

[3] Hosp 12 Octubre imas12, Hypertens Unit, Res Inst, Madrid 28041, Spain

[4] Hosp 12 Octubre imas12, Cardiorenal Translat Lab, Res Inst, Madrid 28041, Spain

[5] European Univ Miguel de Cervantes, Dept Hlth Sci, i HeALTH Res Grp, Valladolid 47012, Spain

[6] Univ Bern, Bern Univ Hosp, Med Div Rehabil & Sports Med, Inselspital, CH-3010 Bern, Switzerland

[7] Charite Univ Med Berlin, Dept Cardiol, Campus Benjamin Franklin CBF, D-12203 Berlin, Germany

[8] Charite Univ Med Berlin, Friede Springer Ctr Cardiovasc Prevent Charite, D-10117 Berlin, Germany

[9] CIBER Frailty & Hlth Aging CIBERFES, Madrid 28007, Spain

[10] Univ Europea Madrid, Fac Sport Sci, Madrid 28670, Spain

来源：

EUROPEAN HEART JOURNAL | 2023年 / 44卷 / 21期

关键词：

Exercise and cardiovascular disease; Primary cardiovascular prevention; Secondary cardiovascular prevention; Cardiovascular mortality; Exercise implementation; CORONARY-ARTERY-DISEASE; CHRONIC HEART-FAILURE; ENDOTHELIAL PROGENITOR CELLS; REGULAR PHYSICAL-ACTIVITY; AORTIC-VALVE STENOSIS; ALL-CAUSE MORTALITY; ACUTE MYOCARDIAL-INFARCTION; LD SCORE REGRESSION; ATRIAL-FIBRILLATION; RATE-VARIABILITY;

D O I：

10.1093/eurheartj/ehad170

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is a pandemic of physical inactivity that appears to parallel the widespread prevalence of cardiovascular disease (CVD). Yet, regular physical activity (PA) and exercise can play an important role not only in primary cardiovascular prevention but also in secondary prevention. This review discusses some of the main cardiovascular effects of PA/exercise and the mechanisms involved, including a healthier metabolic milieu with attenuation of systemic chronic inflammation, as well as adaptations at the vascular (antiatherogenic effects) and heart tissue (myocardial regeneration and cardioprotection) levels. The current evidence for safe implementation of PA and exercise in patients with CVD is also summarized.

引用

页码：1874 / 1889

页数：16

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