Structure, function, and evolution of the metal-binding domain in the nucleosome

被引：0
|
作者：
Saavedra, Raul A. [1 ]
机构：
[1] 5525 Englishman Pl, Rockville, MD 20852 USA
来源：
BIOESSAYS | 2023年 / 45卷 / 05期
关键词：
divalent metal ions; evolution; metal-binding domain; nucleosomes; structure; function; CORE PARTICLE; HISTONES; NICKEL(II);
D O I：
10.1002/bies.202200192
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The eukaryotic nucleosome, the basic unit of chromatin, is thermodynamically stable and plays critical roles in the cell, including the maintenance of DNA topology and regulation of gene expression. At its C2 axis of symmetry, the nucleosome exhibits a domain that can coordinate divalent metal ions. This article discusses the roles of the metal-binding domain in the nucleosome structure, function, and evolution.
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页数：4
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