Structure, function, and evolution of the metal-binding domain in the nucleosome

被引：0
|
作者：
Saavedra, Raul A. [1 ]
机构：
[1] 5525 Englishman Pl, Rockville, MD 20852 USA
来源：
BIOESSAYS | 2023年 / 45卷 / 05期
关键词：
divalent metal ions; evolution; metal-binding domain; nucleosomes; structure; function; CORE PARTICLE; HISTONES; NICKEL(II);
D O I：
10.1002/bies.202200192
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The eukaryotic nucleosome, the basic unit of chromatin, is thermodynamically stable and plays critical roles in the cell, including the maintenance of DNA topology and regulation of gene expression. At its C2 axis of symmetry, the nucleosome exhibits a domain that can coordinate divalent metal ions. This article discusses the roles of the metal-binding domain in the nucleosome structure, function, and evolution.
引用
收藏
页数：4
相关论文
共 50 条
  • [1] Nucleosome Structure and Function
    McGinty, Robert K.
    Tan, Song
    CHEMICAL REVIEWS, 2015, 115 (06) : 2255 - 2273
  • [2] Crystal structure of methylmalonyl-CoA epimerase: a novel enzymatic function on an ancient metal-binding scaffold.
    McCarthy, A. A.
    Baker, H. M.
    Shewry, S. C.
    Patchett, M. L.
    Baker, E. N.
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2000, 56 : S238 - S238
  • [3] Contributions of Histone Variants in Nucleosome Structure and Function
    Kurumizaka, Hitoshi
    Kujirai, Tomoya
    Takizawa, Yoshimasa
    JOURNAL OF MOLECULAR BIOLOGY, 2021, 433 (06)
  • [4] The metal-binding domain of IGFBP-3 selectively delivers therapeutic molecules into cancer cells
    Huq, Ania
    Singh, Baljit
    Meeker, Thea
    Mascarenhas, Desmond
    ANTI-CANCER DRUGS, 2009, 20 (01) : 21 - 31
  • [5] Expanding Protein Functionalities by Rational Design of Artificial Metal-Binding Sites
    Lin Yingwu
    PROGRESS IN CHEMISTRY, 2010, 22 (06) : 1203 - 1211
  • [6] The N-terminal degenerated metal-binding domain is involved in the heavy metal transport activity of TaHMA2
    Xiang, Shuqin
    Feng, Shanshan
    Zhang, Yuxiu
    Tan, Jinjuan
    Liang, Shuang
    Chai, Tuanyao
    PLANT CELL REPORTS, 2015, 34 (09) : 1615 - 1628
  • [7] The N-terminal degenerated metal-binding domain is involved in the heavy metal transport activity of TaHMA2
    Shuqin Xiang
    Shanshan Feng
    Yuxiu Zhang
    Jinjuan Tan
    Shuang Liang
    Tuanyao Chai
    Plant Cell Reports, 2015, 34 : 1615 - 1628
  • [8] A possible regulatory role for the metal-binding domain of CadA, the Listeria monocytogenes Cd2+-ATPase
    Bal, N
    Mintz, E
    Guillain, F
    Catty, P
    FEBS LETTERS, 2001, 506 (03): : 249 - 252
  • [9] McsA and the roles of metal-binding motif in Staphylococcus aureus
    Sitthisak, Sutthirat
    Kitti, Thawatchai
    Boonyonying, Kamala
    Wozniak, Darren
    Mongkolsuk, Skorn
    Jayaswal, Radheshyam K.
    FEMS MICROBIOLOGY LETTERS, 2012, 327 (02) : 126 - 133
  • [10] Consequences of Cisplatin Binding on Nucleosome Structure and Dynamics
    Todd, Ryan C.
    Lippard, Stephen J.
    CHEMISTRY & BIOLOGY, 2010, 17 (12): : 1334 - 1343
12345