The role of LncRNA LBX2-AS1 in cancers: functions, mechanisms and potential clinical utility

被引：8

作者：

Su, Yuanshuai ^{[1
]}

Li, Chengzhi ^{[2
]}

Fang, Yu ^{[1
]}

Gu, Xinyu ^{[1
]}

Zheng, Qiuxian ^{[1
]}

Lu, Juan ^{[1
]}

Li, Lanjuan ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1,Natl Med Ctr Infect Dis, Natl Clin Res Ctr Infect Dis,State Key Lab Diag &, Sch Med,Collaborat Innovat Ctr Diag & Treatment I, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Pathol, Hangzhou 310003, Zhejiang, Peoples R China

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2023年 / 25卷 / 02期

关键词：

Long noncoding RNA; LBX2-AS1; Oncogenic; Molecular mechanism; Cancer therapy; LONG NONCODING RNA; PRECISION ONCOLOGY; CELL-PROLIFERATION; PROSTATE-CANCER; GASTRIC-CANCER; METASTASIS; GLIOMA; EPIDEMIOLOGY; TECHNOLOGIES; EXPRESSION;

D O I：

10.1007/s12094-022-02944-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Increasingly advanced biology technique has revealed that long non-coding RNAs (lncRNA) as critical factors that exert significant regulatory effects on biological functions by modulating gene transcription, epigenetic modifications and protein translation. A newly emerging lncRNA, ladybird homeobox 2 (LBX2)-antisense RNA 1 (LBX2-AS1), was found to be highly expressed in various tumors. Moreover, it is functionally linked to the regulation of essential tumor-related biological processes, such as cell proliferation and apoptosis, through interactions with multiple signaling molecules/pathways. The important roles played by LBX2-AS1 in cancer initiation and progression suggest that this lncRNA has enormous clinical potential for use as a novel biomarker or therapeutic target. In this article, we retrospectively review the latest advances in research exploring the roles of the lncRNA LBX2-AS1 in oncology field, highlighting its involvement in a comprehensive network of molecular mechanisms underlying diverse cancers and examining its potential applications in clinical practice.

引用

页码：293 / 305

页数：13

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