Immune responses related to the immunogenicity and reactogenicity of COVID-19 mRNA vaccines

被引：15

作者：

Matsumura, Takayuki ^{[1
]}

Takano, Tomohiro ^{[1
]}

Takahashi, Yoshimasa ^{[1
]}

机构：

[1] Natl Inst Infect Dis, Res Ctr Drug & Vaccine Dev, 1-23-1 Toyama,Shinjuku Ku, Tokyo 1628640, Japan

来源：

INTERNATIONAL IMMUNOLOGY | 2023年 / 35卷 / 05期

基金：

日本学术振兴会;

关键词：

acquired immunity; adverse event; innate immunity; lipid nanoparticle; SARS-CoV-2 spike protein; T-HELPER TYPE-1; INFLUENZA VACCINATION; CELLS; ACTIVATION; DIFFERENTIATION; RECOGNITION; ANTIBODY; DISTINCT; SUBSET;

D O I：

10.1093/intimm/dxac064

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccination for the prevention of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection is considered the most promising approach to control the pandemic of coronavirus disease 2019 (COVID-19). Although various COVID-19 vaccines have been developed worldwide using several modalities, the vaccines that have shown the highest efficacy to date are mRNA vaccines. Despite their extensive usage, the mechanisms that stimulate the immune responses associated with their immunogenicity and reactogenicity remain largely unknown. In this review, we summarize and discuss current knowledge on immune responses to COVID-19 mRNA vaccines, including potential immune responses and correlating factors underlying the immunogenicity and reactogenicity of mRNA vaccines. We also describe recent trends in the optimization of lipid nanoparticles and vaccination routes. Further understanding of vaccine-elicited immune responses will guide the development of more effective and safe vaccines.

引用

页码：213 / 220

页数：8

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