Antigen-specific T cell responses in SARS-CoV-2 mRNA-vaccinated children

被引：3

作者：

Philpott, Jordan D. ^{[1
]}

Miller, Jordan ^{[1
]}

Boribong, Brittany P. ^{[1
]}

Charles, Saeina ^{[1
]}

Davis, Jameson P. ^{[1
]}

Kazimierczyk, Simon ^{[1
]}

Jimena, Brittany ^{[1
]}

Leonard, Maureen M. ^{[1
,2
]}

Shreffler, Wayne G. ^{[3
]}

Fasano, Alessio ^{[1
,3
]}

Yonker, Lael M. ^{[1
,3
]}

Jain, Nitya ^{[1
,2
,4
]}

机构：

[1] Massachusetts Gen Hosp Children, Mucosal Immunol & Biol Res Ctr, 114 16th St, Charlestown, MA 02129 USA

[2] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA

[3] Massachusetts Gen Hosp, Pediat Allergy & Immunol & Ctr Immunol & Inflammat, 175 Cambridge St, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, 185 Cambridge St, Boston, MA 02114 USA

来源：

CELL REPORTS MEDICINE | 2023年 / 4卷 / 12期

关键词：

IMMUNITY; SIN;

D O I：

10.1016/j.xcrm.2023.101298

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SARS-CoV-2 mRNA vaccines elicit humoral responses in children that are comparable to those in adults. However, early-life T cell responses are distinct from adult ones, and questions remain about the nature and kinetics of mRNA vaccine-induced T cell responses in children. We report that Pfizer BNT162b2 mRNA vaccination elicits a significant antigen-specific CD4+ T cell response in the R12-year-old cohort. This response is weaker in magnitude in the 5-to 11-year-old cohort and is not improved by a higher vaccine dose (Moderna mRNA1273, 100 mg), suggesting distinct developmental programming that may underscore early-life T cell immunity. Increased effector phenotypes of antigen-specific T cells in younger children correspond with elevated anti-receptor binding domain antibody levels, albeit at the cost of memory generation. These studies highlight aspects of age-specific adaptive immune responses and the need for careful consideration of priming conditions including vaccine dose and adjuvant in the pediatric population.

引用

页数：12

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