Venetoclax overcomes resistance to all-trans retinoic acid in a variant acute promyelocytic leukemia with TNRC18::RARA fusion

被引：3

作者：

Xu, Jing ^{[1
,2
]}

Li, He ^{[3
]}

Wang, Zhongwang ^{[1
,2
]}

Wang, Mengyao ^{[1
,2
]}

Li, Qian ^{[3
]}

Hang, Xiaohang ^{[1
,2
]}

Xu, Juan ^{[3
]}

Ji, Jie ^{[3
]}

Chen, Chong ^{[1
,2
]}

Liu, Yu ^{[1
,2
]}

Niu, Ting ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Hematol, State Key Lab Biotherapy, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, Canc Ctr, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Hematol, Chengdu, Sichuan, Peoples R China

来源：

MOLECULAR CARCINOGENESIS | 2024年 / 63卷 / 04期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

acute promyelocytic leukemia; differentiation; RARA; TNRC18; venetoclax;

D O I：

10.1002/mc.23671

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acute promyelocytic leukemia (APL) is generally driven by PML::RARA, but approximately 2% of variant APL patients do not contain this fusion gene and pose challenges in diagnosis and treatment. Here, we reported an aggressive APL patient with variant TNRC18::RARA fusion gene, who was resistant to standard differentiation induction therapy consisting of all-trans retinoic acid (ATRA) and arsenic trioxide but achieved complete remission with venetoclax plus ATRA. Mechanistically, venetoclax possesses synergistic effects in ATRA-induced TNRC18::RARA-positive cell differentiation.

引用

页码：553 / 557

页数：5

共 10 条

[1] Case report: Identification of a novel HNRNPC::RARG fusion in acute promyelocytic leukemia lacking RARA rearrangement [J].

Ding, Wenjing ;

Weng, Guangyang ;

Wang, Zheng ;

Guo, Yusha ;

Wang, Man ;

Shen, Hongjie ;

Chen, Suning ;

Du, Xin ;

Wen, Lijun .

FRONTIERS IN ONCOLOGY, 2023, 12

[2] Differentiation therapy using low-dose venetoclax in a variant acute promyelocytic leukaemia carrying ZBTB16-RARA [J].

Li, He ;

Xiang, Xinrong ;

Ding, Hong ;

Yu, Jiang ;

Xu, Juan ;

Yuan, Ying ;

Wu, Yu .

BRITISH JOURNAL OF HAEMATOLOGY, 2022, 199 (05) :768-771

[3] Relapsed/refractory acute promyelocytic leukemia with RARA-LBD region mutation was salvaged by venetoclax A case report [J].

Li, Youli ;

Yu, Jieni ;

Xu, Qinhong ;

Zhang, Kejie .

MEDICINE, 2021, 100 (48)

[4] A novel HNRNPC-RARA fusion in acute promyelocytic leukaemia lacking PML-RARA rearrangement, sensitive to venetoclax-based therapy [J].

Liu, Meng ;

Zhao, Xiujie ;

Pan, Wenjue ;

Qian, Zijun ;

Du, Mengbao ;

Wang, Li-Mengmeng ;

Huang, He ;

Xiao, Haowen .

BRITISH JOURNAL OF HAEMATOLOGY, 2021, 195 (02) :E123-E128

[5] Clinical Response to Venetoclax and Decitabine in Acute Promyelocytic Leukemia With a Novel RARA-THRAP3 Fusion: A Case Report [J].

Song, Baoquan ;

Wang, Xin ;

Kong, Xin ;

Wang, Man ;

Yao, Li ;

Shen, Hongjie ;

Zhang, Jian ;

Qiu, Huiying .

FRONTIERS IN ONCOLOGY, 2022, 12

[6] Prognostic factors in acute promyelocytic leukemia: strategies to define high-risk patients [J].

Testa, Ugo ;

Lo-Coco, Francesco .

ANNALS OF HEMATOLOGY, 2016, 95 (05) :673-680

[7] Venetoclax for arsenic-resistant acute promyelocytic leukaemia [J].

Wang, Qian Qian ;

Wang, Hua-Feng ;

Zhao, Jian-Zhi ;

Naranmandura, Hua ;

Jin, Jie ;

Zhu, Hong-Hu .

BRITISH JOURNAL OF HAEMATOLOGY, 2022, 197 (05) :E58-E60

[8] Identification of a novel TNRC18-RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML-RARA [J].

Wang, Zheng ;

Wen, Lijun ;

Zhang, Ling ;

Xu, Xiaoyu ;

Chen, Xiaoqian ;

Yao, Li ;

Wang, Man ;

Shen, Zhen ;

Mo, Guangquan ;

Wang, Yao ;

Zhao, Dewan ;

Cai, Wei ;

Shen, Jingzhi ;

Chi, Xiaomeng ;

Xu, Yi ;

Zeng, Zhao ;

Pan, Jinlan ;

Ruan, Changgeng ;

Wu, Depei ;

Jia, Zhilin ;

Chen, Suning .

MOLECULAR CARCINOGENESIS, 2021, 60 (02) :101-105

[9] Treatment of STAT5b-RARA positive acute promyelocytic leukemia by Venetoclax combining with homoharringtonine, cytarabine: A case report and literature review [J].

Zhang, Guangji ;

Song, Yang ;

Wan, Li ;

Liu, Kaiqi ;

Qiu, Shaowei ;

Wang, Jianxiang ;

Mi, Yingchang .

BLOOD SCIENCE, 2022, 4 (02) :93-96

[10] Current views on the genetic landscape and management of variant acute promyelocytic leukemia [J].

Zhang, Xiang ;

Sun, Jiewen ;

Yu, Wenjuan ;

Jin, Jie .

BIOMARKER RESEARCH, 2021, 9 (01)

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