Mechanism of fibroblast growth factor 21 in cardiac remodeling

被引：4
|
作者：
Zhao, Zeyu [1 ]
Cui, Xuemei [2 ]
Liao, Zhangping [3 ]
机构：
[1] Nanchang Univ, Queen Mary Coll, Nanchang, Peoples R China
[2] Nanchang Univ, Clin Med Coll 4, Nanchang, Peoples R China
[3] Nanchang Univ, Sch Pharmaceut Sci, Jiangxi Prov Key Lab Basic Pharmacol, Nanchang, Peoples R China
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2023年 / 10卷
基金：
中国国家自然科学基金;
关键词：
fibroblast growth factor 21 (FGF21); heart remodeling; energy metabolism; oxidation; inflammation; autophagy; OXIDATIVE STRESS; DIABETIC CARDIOMYOPATHY; VENTRICULAR DYSFUNCTION; MYOCARDIAL-INFARCTION; HEART-FAILURE; MITOCHONDRIAL DYSFUNCTION; NADPH OXIDASE; CELL-DEATH; FGF21; INFLAMMATION;
D O I：
10.3389/fcvm.2023.1202730
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiac remodeling is a basic pathological process that enables the progression of multiple cardiac diseases to heart failure. Fibroblast growth factor 21 is considered a regulator in maintaining energy homeostasis and shows a positive role in preventing damage caused by cardiac diseases. This review mainly summarizes the effects and related mechanisms of fibroblast growth factor 21 on pathological processes associated with cardiac remodeling, based on a variety of cells of myocardial tissue. The possibility of Fibroblast growth factor 21 as a promising treatment for the cardiac remodeling process will also be discussed.
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收藏
页数：9
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