Antimicrobial activity of cinnamaldehyde against multidrug-resistant Klebsiella pneumoniae: an in vitro and in vivo study

被引：4

作者：

Mattos Vaz, Marcia Soares ^{[1
]}

de Almeida de Souza, Gleyce Hellen ^{[1
]}

dos Santos Radai, Joyce Alencar ^{[1
]}

Fraga, Thiago Leite ^{[2
]}

de Oliveira, Gustavo Gomes ^{[2
]}

Wender, Heberton ^{[3
]}

da Silva, Kesia Esther ^{[1
,4
]}

Simionatto, Simone ^{[1
]}

机构：

[1] Univ Fed Grande Dourados UFGD, Lab Pesquisa Ciencias Saude, Itahum, Cidade Univ,Km 12, BR-79804970 Dourados, MS, Brazil

[2] Ctr Univ Grande Dourados UNIGRAN, Dourados, MS, Brazil

[3] Univ Fed Mato Grosso Do Sul, Inst Fis, Grp Pesquisa Nano & Fotons, Campo Grande, Brazil

[4] Stanford Univ, Div Infect Dis & Geog Med, Stanford, CA 94304 USA

来源：

BRAZILIAN JOURNAL OF MICROBIOLOGY | 2023年 / 54卷 / 03期

关键词：

Cinnamaldehyde; Multidrug-resistant; Gram-negative; Infection; ESCHERICHIA-COLI; INHIBITION; COMPONENTS; ACID;

D O I：

10.1007/s42770-023-01040-z

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The emergence and spread of multidrug-resistant (MDR) Klebsiella pneumoniae strains have increased worldwide, posing a significant health threat by limiting the therapeutic options. This study aimed to investigate the antimicrobial potential of cinnamaldehyde against MDR-K. pneumoniae strains in vitro and in vivo assays. The presence of resistant genes in MDR- K. pneumoniae strains were evaluated by Polymerase Chain Reaction (PCR) and DNA sequencing. Carbapenem-resistant K. pneumoniae strains show the bla(KPC-2) gene, while polymyxin-resistant K. pneumoniae presented bla(KPC-2) and alterations in the mgrB gene. Cinnamaldehyde exhibited an inhibitory effect against all MDR- K. pneumoniae evaluated. An infected mice model was used to determine the in vivo effects against two K. pneumoniae strains, one carbapenem-resistant and another polymyxin-resistant. After 24 h of cinnamaldehyde treatment, the bacterial load in blood and peritoneal fluids decreased. Cinnamaldehyde showed potential effectiveness as an antibacterial agent by inhibiting the growth of MDR-K. pneumoniae strains.

引用

页码：1655 / 1664

页数：10

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