The role of heterochromatin in 3D genome organization during preimplantation development

被引：1
|
作者：
Rang, Franka J. [1 ,2 ,3 ]
Kind, Jop [1 ,2 ,3 ,4 ]
Guerreiro, Isabel [1 ,2 ,3 ]
机构：
[1] Royal Netherlands Acad Arts & Sci KNAW, Hubrecht Inst, Uppsalalaan 8, NL-3584 CT Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Uppsalalaan 8, NL-3584 CT Utrecht, Netherlands
[3] Oncode Inst, Utrecht, Netherlands
[4] Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Fac Sci, Dept Mol Biol, Houtlaan 4, NL-6525 XZ Nijmegen, Netherlands
来源：
CELL REPORTS | 2023年 / 42卷 / 04期
关键词：
NUCLEAR LAMINA INTERACTIONS; POLYCOMB-GROUP PROTEINS; PHASE-SEPARATION; CONSTITUTIVE HETEROCHROMATIN; CHROMATIN ARCHITECTURE; HISTONE MODIFICATIONS; MOUSE EMBRYOS; LOOP; REVEALS; DOMAIN;
D O I：
10.1016/j.celrep.2023.112248
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
During the early stages of mammalian development, the epigenetic state of the parental genome is completely reprogrammed to give rise to the totipotent embryo. An important aspect of this remodeling con-cerns the heterochromatin and the spatial organization of the genome. While heterochromatin and genome organization are intricately linked in pluripotent and somatic systems, little is known about their relationship in the totipotent embryo. In this review, we summarize the current knowledge on the reprogramming of both regulatory layers. In addition, we discuss available evidence on their relationship and put this in the context of findings in other systems.
引用
收藏
页码：1 / 12
页数：12
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