Synthetic dibenzylideneketones as promising anti-herpes simplex virus type 1 agents

被引：0

作者：

Oliveira, Thalita Zago ^{[1
]}

Fonseca, Dyenefer Pereira ^{[1
]}

dos Santos, Andre Henrique ^{[1
]}

da Silva, Thays Rosa ^{[1
]}

Lazarin-Bidoia, Danielle ^{[1
]}

Din, Zia Ud ^{[2
]}

Dias Filho, Benedito Prado ^{[1
]}

Nakamura, Celso Vataru ^{[1
]}

Rodrigues-Filho, Edson ^{[2
]}

Ueda-Nakamura, Tania ^{[1
]}

机构：

[1] Univ Estadual Maringa, Dept Basic Hlth Sci, Lab Technol Innovat Dev Drugs & Cosmet, Ave Colombo 5790, BR-87020900 Maringa, PR, Brazil

[2] Univ Fed Sao Carlos, Lab Micromol Biochem Microorganisms, Sao Carlos, SP, Brazil

来源：

ARCHIVES OF VIROLOGY | 2023年 / 168卷 / 05期

关键词：

IN-VITRO; GROWTH;

D O I：

10.1007/s00705-023-05777-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

New antiviral agents for the treatment of herpes simplex virus type 1 (HSV-1) infection, which causes a highly prevalent and incurable disease, are needed. Here, we report for the first time the in vitro anti-HSV-1 activity of two dibenzylideneketone compounds: DBK1 and DBK2. DBK1 demonstrated virucidal activity, and high-resolution scanning electron microscopy showed that it caused morphological changes in the HSV-1 envelope. DBK2 was able to reduce HSV-1 plaque size in vitro. The DBKs are promising anti-HSV-1 candidates, as they exhibit low toxicity and exert an antiviral effect by acting at the early stages of HSV-1-host cell interaction.

引用

页数：5

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