Design, synthesis, and anti-aging effect evaluation of urolithin B and its amide derivatives on nematode Caenorhabditis elegans

被引：3

作者：

Chen, Xi ^{[1
,2
]}

Feng, Xiaoqing ^{[1
,2
]}

Kong, Xiangming ^{[3
]}

Wang, Hecheng ^{[1
,2
]}

Liu, Tianwen ^{[1
,2
]}

Tang, Long ^{[1
,2
]}

Zhuang, Ziheng ^{[1
,2
,3
,4
]}

机构：

[1] Changzhou Univ, Sch Pharm, Changzhou 213164, Peoples R China

[2] Changzhou Univ, Sch Biol & Food Engn, Changzhou 213164, Peoples R China

[3] Changzhou Railway Higher Vocat & Tech Sch, Changzhou 213011, Peoples R China

[4] Changzhou Tradit Chinese Med Hosp, Changzhou 213004, Peoples R China

来源：

MEDICINAL CHEMISTRY RESEARCH | 2023年 / 32卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Urolithin B; Amide derivatives; Anti-aging; Biosafety; Caenorhabditis elegans; LIFE-SPAN;

D O I：

10.1007/s00044-023-03056-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aging is a natural process, but with the increase of people's average life expectancy, aging has brought great economic pressure and social burden to many countries and regions. As urolithin B (UB) is a natural metabolite, it has shown positive effects in many disease studies, such as obesity, diabetes, osteoporosis, cancer, learning and memory disorders, and other diseases. This inspired researchers to further study and application of UB as a potential anti-aging drug. In this study, 13 amide derivatives of UB were designed and synthesized, and their anti-aging and biosafety were verified using Caenorhabditis elegans (C. elegans). C. elegans is a powerful model organism for anti-aging research. Finally, our results showed that Cpd. 11 had the best anti-aging activity among the thirteen amide derivatives, and the compound had good biosafety. Therefore, Cpd. 11 has the potential to be used as an anti-aging drug and needs to be further developed and applied.

引用

页码：1087 / 1097

页数：11

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