Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer's Disease

被引：20

作者：

Romero-Marquez, Jose M. ^{[1
]}

Forbes-Hernandez, Tamara Y. ^{[1
]}

Navarro-Hortal, Maria D. ^{[1
]}

Quirantes-Pine, Rosa ^{[2
]}

Grosso, Giuseppe ^{[3
,4
]}

Giampieri, Francesca ^{[5
]}

Lipari, Vivian ^{[5
,6
,7
]}

Sanchez-Gonzalez, Cristina ^{[1
,8
]}

Battino, Maurizio ^{[9
,10
]}

Quiles, Jose L. ^{[1
,2
,5
]}

机构：

[1] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Biomed Res Ctr, Dept Physiol, Armilla 18016, Spain

[2] Res & Dev Funct Food Ctr CIDAF, Hlth Sci Technol Pk,Ave Conocimiento 37, Granada 18016, Spain

[3] Univ Catania, Dept Biomed & Biotechnol Sci, I-95123 Catania, Italy

[4] Univ Catania, Ctr Human Nutr & Mediterranean Foods NUTREA, I-95123 Catania, Italy

[5] Univ Europea Atlantico, Res Grp Foods Nutr Biochem & Hlth, Isabel Torres 21, Santander 39011, Spain

[6] Univ Int Iberoamer, Dept Project Management, Campeche 24560, Mexico

[7] Univ Int Cuanza, Dept Prohect Management, Cuito 250, Bie, Angola

[8] Univ Granada, Sport & Hlth Res Ctr, C Menendez Pelayo 32, Granada 18016, Spain

[9] Polytech Univ Marche, Dept Clin Sci, I-60131 Ancona, Italy

[10] Jiangsu Univ, Int Joint Res Lab Intelligent Agr & Agri Prod Pro, Zhenjiang 212013, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 05期

基金：

欧盟地平线“2020”;

关键词：

olive leaves; bioactive compounds; Alzheimer's Disease; oleuropein; hydroxytyrosol; EUROPAEA-L; LEAF; OLEA-EUROPAEA; OXIDATIVE STRESS; SAFETY ASSESSMENT; DOUBLE-BLIND; EXTRACT; OLEUROPEIN; BRAIN; BIOAVAILABILITY; LEAVES;

D O I：

10.3390/ijms24054353

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's Disease (AD) is the cause of around 60-70% of global cases of dementia and approximately 50 million people have been reported to suffer this disease worldwide. The leaves of olive trees (Olea europaea) are the most abundant by-products of the olive grove industry. These by-products have been highlighted due to the wide variety of bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT) with demonstrated medicinal properties to fight AD. In particular, the olive leaf (OL), OLE, and HT reduced not only amyloid-beta formation but also neurofibrillary tangles formation through amyloid protein precursor processing modulation. Although the isolated olive phytochemicals exerted lower cholinesterase inhibitory activity, OL demonstrated high inhibitory activity in the cholinergic tests evaluated. The mechanisms underlying these protective effects may be associated with decreased neuroinflammation and oxidative stress via NF-kappa B and Nrf2 modulation, respectively. Despite the limited research, evidence indicates that OL consumption promotes autophagy and restores loss of proteostasis, which was reflected in lower toxic protein aggregation in AD models. Therefore, olive phytochemicals may be a promising tool as an adjuvant in the treatment of AD.

引用

页数：22

共 91 条

[31] Seed Phytochemical Profiling of Three Olive Cultivars, Antioxidant Capacity, Enzymatic Inhibition, and Effects on Human Neuroblastoma Cells (SH-SY5Y) [J].