共 30 条
Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction
被引:110
作者:

Cai, Shanshan
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Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA

Zhao, Mingyue
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Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA
Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Peoples R China Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA

Zhou, Bo
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Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA

Yoshii, Akira
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Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA

Bugg, Darrian
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Univ Washington, Sch Med, Dept Lab Med & Pathol, Seattle, WA USA Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA

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Sahu, Anita
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Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA

Olson, Gregory S.
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Seattle Childrens Res Inst, Ctr Global Infect Dis Res, Seattle, WA USA
Univ Washington, Sch Med, Med Scientist Training Program, Seattle, WA USA Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA

Davis, Jennifer
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Univ Washington, Sch Med, Dept Lab Med & Pathol, Seattle, WA USA Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA

Tian, Rong
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h-index: 0
机构:
Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA
Univ Washington, Mitochondria & Metab Ctr, Seattle, WA 98109 USA Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA
机构:
[1] Univ Washington, Sch Med, Ctr Mitochondria & Metab Ctr, Dept Anesthesiol & Pain Med, Seattle, WA USA
[2] Univ Washington, Sch Med, Dept Lab Med & Pathol, Seattle, WA USA
[3] Seattle Childrens Res Inst, Ctr Global Infect Dis Res, Seattle, WA USA
[4] Univ Washington, Sch Med, Med Scientist Training Program, Seattle, WA USA
[5] Univ Washington, Mitochondria & Metab Ctr, Seattle, WA 98109 USA
[6] Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Guangzhou 510060, Peoples R China
关键词:
CARDIAC MACROPHAGE;
D O I:
10.1172/JCI167079
中图分类号:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号:
1001 ;
摘要:
Innate immune cells play important roles in tissue injury and repair following acute myocardial infarction (MI). Although reprogramming of macrophage metabolism has been observed during inflammation and resolution phases, the mechanistic link to macrophage phenotype is not fully understood. In this study, we found that myeloid-specific deletion (mKO) of mitochondrial complex I protein, encoded by Ndufs4, reproduced the proinflammatory metabolic profile in macrophages and exaggerated the response to LPS. Moreover, mKO mice showed increased mortality, poor scar formation, and worsened cardiac function 30 days after MI. We observed a greater inflammatory response in mKO mice on day 1 followed by increased cell death of infiltrating macrophages and blunted transition to the reparative phase during post-MI days 3-7. Efferocytosis was impaired in mKO macrophages, leading to lower expression of antiinflammatory cytokines and tissue repair factors, which suppressed the proliferation and activation of myofibroblasts in the infarcted area. Mitochondria-targeted ROS scavenging rescued these impairments, improved myofibroblast function in vivo, and reduced post-MI mortality in mKO mice. Together these results reveal a critical role of mitochondria in inflammation resolution and tissue repair via modulation of efferocytosis and crosstalk with fibroblasts. These findings have potential significance for post-MI recovery as well as for other inflammatory conditions.
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