Anticancer Therapy Targeting Cancer-Derived Extracellular Vesicles

被引：17
作者：
Cheng, Xiao [1 ,2 ]
Henick, Brian S. [3 ]
Cheng, Ke [4 ]
机构：
[1] Univ North Carolina Chapel Hill, Joint Dept Biomed Engn, Chapel Hill, NC 27599 USA
[2] North Carolina State Univ, Joint Dept Biomed Engn, Raleigh, NC 27606 USA
[3] Columbia Univ, Irving Med Ctr, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA
[4] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA
来源：
ACS NANO | 2024年 / 18卷 / 09期
基金：
美国国家卫生研究院;
关键词：
Extracellular vesicles; Cancer therapy; Nanomedicine; Cancer metastasis; Biomaterials; Drug delivery; Cancer Vaccine; Immunotherapy; TUMOR-ANTIGENS; MICRORNA BIOGENESIS; EXOSOME BIOGENESIS; DELIVERY; SECRETION; CELLS; INHIBITION; VACCINE; MICROVESICLE; DOXORUBICIN;
D O I：
10.1021/acsnano.3c06462
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Extracellular vesicles (EVs) are natural lipid nanoparticles secreted by most types of cells. In malignant cancer, EVs derived from cancer cells contribute to its progression and metastasis by facilitating tumor growth and invasion, interfering with anticancer immunity, and establishing premetastasis niches in distant organs. In recent years, multiple strategies targeting cancer-derived EVs have been proposed to improve cancer patient outcomes, including inhibiting EV generation, disrupting EVs during trafficking, and blocking EV uptake by recipient cells. Developments in EV engineering also show promising results in harnessing cancer-derived EVs as anticancer agents. Here, we summarize the current understanding of the origin and functions of cancer-derived EVs and review the recent progress in anticancer therapy targeting these EVs.
引用
收藏
页码：6748 / 6765
页数：18
相关论文
共 206 条
  • [61] Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo
    Hyenne, Vincent
    Ghoroghi, Shima
    Collot, Mayeul
    Bons, Joanna
    Follain, Gautier
    Harlepp, Sebastien
    Mary, Benjamin
    Bauer, Jack
    Mercier, Luc
    Busnelli, Ignacio
    Lefebvre, Olivier
    Fekonja, Nina
    Garcia-Leon, Maria J.
    Machado, Pedro
    Delalande, Francois
    Amor Lopez, Ana
    Garcia Silva, Susana
    Verweij, Frederik J.
    van Niel, Guillaume
    Djouad, Farida
    Peinado, Hector
    Carapito, Christine
    Klymchenko, Andrey S.
    Goetz, Jacky G.
    [J]. DEVELOPMENTAL CELL, 2019, 48 (04) : 554 - +
  • [62] Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A
    Im, Eun-Ju
    Lee, Chan-Hyeong
    Moon, Pyong-Gon
    Rangaswamy, Gunassekaran Gowri
    Lee, Byungheon
    Lee, Jae Man
    Lee, Jae-Chul
    Jee, Jun-Goo
    Bae, Jong-Sup
    Kwon, Taeg-Kyu
    Kang, Keon-Wook
    Jeong, Myeong-Seon
    Lee, Joo-Eun
    Jung, Hyun-Suk
    Ro, Hyun-Joo
    Jun, Sangmi
    Kang, Wonku
    Seo, Seung-Yong
    Cho, Young-Eun
    Song, Byoung-Joon
    Baek, Moon-Chang
    [J]. NATURE COMMUNICATIONS, 2019, 10 (1)
  • [63] Syntenin mediates SRC function in exosomal cell-to-cell communication
    Imjeti, Naga Sailaja
    Menck, Kerstin
    Egea-Jimenez, Antonio Luis
    Lecointre, Celine
    Lembo, Frederique
    Bouguenina, Habib
    Badache, Ali
    Ghossoub, Rania
    David, Guido
    Roche, Serge
    Zimmermann, Pascale
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (47) : 12495 - 12500
  • [64] Delivering nanomedicine to solid tumors
    Jain, Rakesh K.
    Stylianopoulos, Triantafyllos
    [J]. NATURE REVIEWS CLINICAL ONCOLOGY, 2010, 7 (11) : 653 - 664
  • [65] Reassessment of Exosome Composition
    Jeppesen, Dennis K.
    Fenix, Aidan M.
    Franklin, Jeffrey L.
    Higginbotham, James N.
    Zhang, Qin
    Zimmerman, Lisa J.
    Liebler, Daniel C.
    Ping, Jie
    Liu, Qi
    Evans, Rachel
    Fissell, William H.
    Patton, James G.
    Rome, Leonard H.
    Burnette, Dylan T.
    Coffey, Robert J.
    [J]. CELL, 2019, 177 (02) : 428 - +
  • [66] Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo
    Jorfi, Samireh
    Ansa-Addo, Ephraim A.
    Kholia, Sharad
    Stratton, Dan
    Valley, Shaunelle
    Lange, Sigrun
    Inal, Jameel
    [J]. SCIENTIFIC REPORTS, 2015, 5
  • [67] Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes
    Joshi, Bhagyashree S.
    de Beer, Marit A.
    Giepmans, Ben N. G.
    Zuhorn, Inge S.
    [J]. ACS NANO, 2020, 14 (04) : 4444 - 4455
  • [68] Development and MPI tracking of novel hypoxia-targeted theranostic exosomes
    Jung, Kyung Oh
    Jo, Hunho
    Yu, Jung Ho
    Gambhir, Sanjiv Sam
    Pratx, Guillem
    [J]. BIOMATERIALS, 2018, 177 : 139 - 148
  • [69] Exosomes in tumor microenvironment influence cancer progression and metastasis
    Kahlert, Christoph
    Kalluri, Raghu
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2013, 91 (04): : 431 - 437
  • [70] The role of extracellular vesicles in cancer
    Kalluri, Raghu
    McAndrews, Kathleen M.
    [J]. CELL, 2023, 186 (08) : 1610 - 1626
234567891011