The role of tumor-associated macrophages in hepatocellular carcinoma progression: A narrative review

被引：8

作者：

Zhang, Xinyi ^{[1
]}

Yu, Chao ^{[1
]}

Zhao, Siqi ^{[1
]}

Wang, Min ^{[1
]}

Shang, Longcheng ^{[1
,2
]}

Zhou, Jin ^{[1
,2
]}

Ma, Yong ^{[1
,2
]}

机构：

[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Gen Surg, Nanjing, Peoples R China

[2] Nanjing First Hosp, Dept Gen Surg, 68 Changle Rd, Nanjing 210000, Jiangsu, Peoples R China

来源：

CANCER MEDICINE | 2023年 / 12卷 / 24期

关键词：

drug resistance; hepatocellular carcinoma; signaling pathway; tumor microenvironment; tumor-associated macrophages; NF-KAPPA-B; EPITHELIAL-MESENCHYMAL TRANSITION; FATTY-ACID-METABOLISM; CANCER STEM-CELLS; M2; POLARIZATION; UP-REGULATION; PROMOTES; GROWTH; CONTRIBUTES; SUPPRESSES;

D O I：

10.1002/cam4.6717

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, with complex etiology and mechanism, and a high mortality rate. Tumor-associated macrophages (TAMs) are an important part of the HCC tumor microenvironment. Studies in recent years have shown that TAMs are involved in multiple stages of HCC and are related to treatment and prognosis in HCC. The specific mechanisms between TAMs and HCC are gradually being revealed. This paper reviews recent advances in the mechanisms associated with TAMs in HCC, concentrating on an overview of effects of TAMs on drug resistance in HCC and the signaling pathways linked with HCC, providing clues for the treatment and prognosis determination of HCC.

引用

页码：22109 / 22129

页数：21

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