The role of tumor-associated macrophages in hepatocellular carcinoma progression: A narrative review

被引：8

作者：

Zhang, Xinyi ^{[1
]}

Yu, Chao ^{[1
]}

Zhao, Siqi ^{[1
]}

Wang, Min ^{[1
]}

Shang, Longcheng ^{[1
,2
]}

Zhou, Jin ^{[1
,2
]}

Ma, Yong ^{[1
,2
]}

机构：

[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Gen Surg, Nanjing, Peoples R China

[2] Nanjing First Hosp, Dept Gen Surg, 68 Changle Rd, Nanjing 210000, Jiangsu, Peoples R China

来源：

CANCER MEDICINE | 2023年 / 12卷 / 24期

关键词：

drug resistance; hepatocellular carcinoma; signaling pathway; tumor microenvironment; tumor-associated macrophages; NF-KAPPA-B; EPITHELIAL-MESENCHYMAL TRANSITION; FATTY-ACID-METABOLISM; CANCER STEM-CELLS; M2; POLARIZATION; UP-REGULATION; PROMOTES; GROWTH; CONTRIBUTES; SUPPRESSES;

D O I：

10.1002/cam4.6717

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, with complex etiology and mechanism, and a high mortality rate. Tumor-associated macrophages (TAMs) are an important part of the HCC tumor microenvironment. Studies in recent years have shown that TAMs are involved in multiple stages of HCC and are related to treatment and prognosis in HCC. The specific mechanisms between TAMs and HCC are gradually being revealed. This paper reviews recent advances in the mechanisms associated with TAMs in HCC, concentrating on an overview of effects of TAMs on drug resistance in HCC and the signaling pathways linked with HCC, providing clues for the treatment and prognosis determination of HCC.

引用

页码：22109 / 22129

页数：21

共 50 条

[21] Targeting tumor-associated macrophages in the tumor microenvironment
Zhou, Kaiwen
Cheng, Tan
Zhan, Jinyue
Peng, Xuan
Zhang, Yue
Wen, Jianpei
Chen, Xiaoman
Ying, Muying
ONCOLOGY LETTERS, 2020, 20 (05)
[22] Role of tumor-associated macrophages in tumor progression and invasion
Alberto Mantovani
Tiziana Schioppa
Chiara Porta
Paola Allavena
Antonio Sica
Cancer and Metastasis Reviews, 2006, 25 : 315 - 322
[23] Role of chemokines in the crosstalk between tumor and tumor-associated macrophages
Qin, Rui
Ren, Weihong
Ya, Guoqi
Wang, Bei
He, Jiao
Ren, Shaoxin
Jiang, Lu
Zhao, Shuo
CLINICAL AND EXPERIMENTAL MEDICINE, 2023, 23 (05) : 1359 - 1373
[24] Immunometabolic attributes and mitochondria-associated signaling of Tumor-Associated Macrophages in tumor microenvironment modulate cancer progression
Dubey, Srijan
Ghosh, Sayak
Goswami, Debosmita
Ghatak, Debapriya
De, Rudranil
BIOCHEMICAL PHARMACOLOGY, 2023, 208
[25] Research progress on the role of tumor-associated macrophages in tumor development and their use as molecular targets (Review)
Lu, Chenglin
Liu, Ying
Miao, Linxuan
Kong, Xiangle
Li, Huili
Chen, Haoran
Zhao, Xu
Zhang, Bin
Cui, Xiaonan
INTERNATIONAL JOURNAL OF ONCOLOGY, 2024, 64 (02)
[26] Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib
Zhou, Shao-Lai
Zhou, Zheng-Jun
Hu, Zhi-Qiang
Huang, Xiao-Wu
Wang, Zheng
Chen, Er-Bao
Fan, Jia
Cao, Ya
Dai, Zhi
Zhou, Jian
GASTROENTEROLOGY, 2016, 150 (07) : 1646 - +
[27] The role of tumor-associated macrophages in osteosarcoma progression – therapeutic implications
Qingshan Huang
Xin Liang
Tingting Ren
Yi Huang
Hongliang Zhang
Yiyang Yu
Chenglong Chen
Wei Wang
Jianfang Niu
Jingbing Lou
Wei Guo
Cellular Oncology, 2021, 44 : 525 - 539
[28] The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer
Nowak, Marek
Klink, Magdalena
CELLS, 2020, 9 (05)
[29] Biological impact and therapeutic implication of tumor-associated macrophages in hepatocellular carcinoma
Li, Deming
Zhang, Ting
Guo, Ye
Bi, Cong
Liu, Ming
Wang, Gang
CELL DEATH & DISEASE, 2024, 15 (07):
[30] Association of tumor-associated fibroblasts with progression of hepatocellular carcinoma
Xiao-Yu Yang
Dong Zhang
Qi-Fei Zou
Fei Fan
Feng Shen
Medical Oncology, 2013, 30

← 1 2 3 4 5 →