Questioning cognitive heterogeneity and intellectual functioning in fetal alcohol spectrum disorders from the Wechsler intelligence scale for children

被引：2

作者：

Kerdreux, Eliot ^{[1
,2
,8
]}

Fraize, Justine ^{[1
,2
]}

Garzon, Pauline ^{[1
,2
]}

Chalain, Esther ^{[3
]}

Etchebarren, Lea ^{[4
]}

Sitbon, Delphine ^{[4
]}

Maruani, Anna ^{[5
]}

Boespflug-Tanguy, Odile ^{[6
]}

Hertz-Pannier, Lucie ^{[1
,2
]}

Noulhiane, Marion ^{[1
,2
]}

Pinabiaux, Charlotte ^{[7
]}

Germanaud, David ^{[1
,2
,3
,8
]}

机构：

[1] CEA Paris Saclay, Freder Joliot Inst, NeuroSpin, UNIACT, Gif Sur Yvette, France

[2] Univ Paris Cite, Inserm, NeuroDiderot, inDEV, Paris, France

[3] Robert Debre Hosp, AP HP, Dept Genet, Ctr Excellence InovAND, Paris, France

[4] Robert Debre Hosp, AP HP, Ctr Excellence InovAND, Pediat Neurol Dept, Paris, France

[5] Robert Debre Hosp, AP HP, Ctr Excellence InovAND, Child & Adolescent Psychiat Dept, Paris, France

[6] Univ Paris Cite, Inserm, NeuroDiderot, NeuroDEV, Paris, France

[7] Univ Paris Nanterre, Dept Psychol, DysCo Lab, Nanterre, France

[8] CEA Paris Saclay, Freder Joliot Inst, NeuroSpin, UNIACT, F-91191 Gif Sur Yvette, France

来源：

CLINICAL NEUROPSYCHOLOGIST | 2024年 / 38卷 / 05期

关键词：

Fetal alcohol spectrum disorders; prenatal alcohol exposure; intellectual abilities; WISC profile heterogeneity; elementary reasoning abilities; NEUROPSYCHOLOGICAL TEST BATTERIES; WISC-IV; LOW SCORES; LEARNING DISORDER; IQ; EXPOSURE; VALIDITY; PROFILE; VARIABILITY; DIAGNOSIS;

D O I：

10.1080/13854046.2023.2281703

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Introduction: Fetal Alcohol Spectrum Disorders (FASD) are characterized by a variety of multiple cognitive and behavioral impairments, with intellectual, attentional, and executive impairments being the most commonly reported. In populations with multiple neurodevelopmental disorders, the Full Scale Intelligence Quotient (FSIQ) may not be a proper measure of intellectual abilities, rarely interpreted in FASD clinical practice because the heterogeneity of the cognitive profile is deemed too strong. We propose a quantitative characterization of this heterogeneity, of the strengths and weaknesses profile, and a differential analysis between global cognitive (FSIQ) and elementary reasoning abilities in a large retrospective monocentric FASD sample. Methods: Using clinical and cognitive data (Wechsler Intelligence Scale for Children) from 107 children with FASD, we characterized subject heterogeneity (variance and scatter of scaled/composite scores), searched for strengths and weaknesses, and specified intellectual functioning in terms of FSIQ and elementary reasoning (General Abilities Index, Highest Reasoning Scaled Score), in comparison with standardization norms and a Monte-Carlo-simulated sample from normalization data. Results: Performance of children with FASD was lower on all subtests, with a significant weakness in working memory and processing speed. We found no increase in the variance and scatter of the scores, but a discordance between the assessment of global cognitive functioning (28% borderline, 23% deficient) and that of global and elementary reasoning abilities (23-9% borderline, 15-14% deficient). Conclusion: Our results question the notion of WISC profile heterogeneity in FASD and point to working memory and processing speed over-impairment, with global repercussions but most often preserved elementary reasoning abilities.

引用

页码：1109 / 1132

页数：24

共 75 条

[1] Diagnosing the full spectrum of fetal alcohol-exposed individuals: Introducing the 4-Digit Diagnostic Code [J].