The significance of CDT1 expression in non-cancerous and cancerous liver in cases with hepatocellular carcinoma

被引：2

作者：

Ogawa, Masahiro ^{[1
]}

Moriyama, Mitsuhiko ^{[1
,2
]}

Kanda, Tatsuo ^{[1
]}

Midorikawa, Yutaka ^{[1
]}

Masuzaki, Ryota ^{[1
]}

Nakamura, Hitomi ^{[3
]}

Shibata, Toshikatu ^{[1
]}

Yamazaki, Motomi ^{[1
]}

Kuroda, Kazumichi ^{[1
]}

Kogure, Hirofumi ^{[1
]}

Nakayama, Hisashi ^{[4
]}

Kanemaru, Kazunori ^{[5
]}

Miki, Toshio ^{[5
]}

Sugitani, Masahiko ^{[6
]}

Takayama, Tadatoshi ^{[4
]}

机构：

[1] Nihon Univ, Dept Med, Div Gastroenterol & Hepatol, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan

[2] Sashi Recuperat Hosp, 1348-1 Hourai,Nishi Ku, Saitama, Saitama 3310074, Japan

[3] Div Gastroenterol & Oyaguchi Kamimachi, Itabashi Ku, Tokyo 1738610, Japan

[4] Nihon Univ, Dept Digest Surg, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan

[5] Nihon Univ, Dept Physiol, Div Biomed Sci, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan

[6] Nihon Univ, Dept Pathol, Sch Med, 30-1 Oyaguchi Kamimachi,Itabashi Ku, Tokyo 1738610, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2023年 / 73卷 / 03期

关键词：

chromatin licensing and DNA replication factor 1; hepatocellular carcinoma; proliferation of atypical hepatocytes; Ki-67; P57; kip2; IRREGULAR REGENERATION; CDK INHIBITORS; HEPATOCYTES; MARKERS; RISK;

D O I：

10.3164/jcbn.23-43

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We previously reported that chromatin licensing and DNA replication factor 1 (CDT1) expression was associated with the extent of proliferation of atypical hepatocytes and the time to postoperative recurrence in cases of hepatocellular carcinoma (HCC). This study aimed to clarify the clinical significance or pathogenesis of CDT1 expression in noncancerous and cancerous liver cases with HCC. We investigated the association between the expression of CDT1 in non-cancerous or cancerous liver tissues and long-term outcome, histologic findings or biochemical examination results in 62 cases. We also examined the dual localization between CDT1 and ki-67, FbxW7, P57kip2, P53 and cMyc by confocal laser scanning microscopy. CDT1 mRNA expression was significantly higher in cancerous liver than in non-cancerous liver (P<0.0001). High CDT1 mRNA expression reveals the strong degree of inflammatory cell infiltration in lobules, high levels of serum transaminase, to show hepatic spare decline and poor long-term prognosis. CDT1 mRNA was highly expressed in a group of poorly differentiated cancer cells. CDT1 co-localized with Ki-67, P57kip2, Fbwx7, P53 and c-Myc in the nucleus or cytoplasm of hepatocytes and cancer cells. We found that CDT1 mRNA expression could represent the degree of hepatic spare ability and the high carcinogenic state.

引用

页码：234 / 248

页数：15

共 27 条

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