Biomarkers for patients with Wilms tumor: a review

被引：11

作者：

Zheng, Hongfeng ^{[1
]}

Liu, Jiangui ^{[1
]}

Pan, Xiuwu ^{[1
]}

Cui, Xingang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Urol, Shanghai, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2023年 / 13卷

基金：

上海市自然科学基金; 中国国家自然科学基金;

关键词：

Wilms tumor; genetic abnormalities; biomarkers; stratification system; liquid biopsy; LONG NONCODING RNA; CHILDRENS ONCOLOGY GROUP; POOR-PROGNOSIS; GROWTH-FACTOR; GENE; MUTATIONS; CANCER; EXPRESSION; KIDNEY; SERUM;

D O I：

10.3389/fonc.2023.1137346

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Wilms tumor, originating from aberrant fetal nephrogenesis, is the most common renal malignancy in childhood. The overall survival of children is approximately 90%. Although existing risk-stratification systems are helpful in identifying patients with poor prognosis, the recurrence rate of Wilms tumors remains as high as 15%. To resolve this clinical problem, diverse studies on the occurrence and progression of the disease have been conducted, and the results are encouraging. A series of molecular biomarkers have been identified with further studies on the mechanism of tumorigenesis. Some of these show prognostic value and have been introduced into clinical practice. Identification of these biomarkers can supplement the existing risk-stratification systems. In the future, more biomarkers will be discovered, and more studies are required to validate their roles in improving the detection rate of occurrence or recurrence of Wilms tumor and to enhance clinical outcomes.

引用

页数：9

共 89 条

[1] Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution [J].

Abbosh, Christopher ;

Birkbak, Nicolai J. ;

Wilson, Gareth A. ;

Jamal-Hanjani, Mariam ;

Constantin, Tudor ;

Salari, Raheleh ;

Le Quesne, John ;

Moore, David A. ;

Veeriah, Selvaraju ;

Rosenthal, Rachel ;

Marafioti, Teresa ;

Kirkizlar, Eser ;

Watkins, Thomas B. K. ;

McGranahan, Nicholas ;

Ward, Sophia ;

Martinson, Luke ;

Riley, Joan ;

Fraioli, Francesco ;

Al Bakir, Maise ;

Gronroos, Eva ;

Zambrana, Francisco ;

Endozo, Raymondo ;

Bi, Wenya Linda ;

Fennessy, Fiona M. ;

Sponer, Nicole ;

Johnson, Diana ;

Laycock, Joanne ;

Shafi, Seema ;

Czyzewska-Khan, Justyna ;

Rowan, Andrew ;

Chambers, Tim ;

Matthews, Nik ;

Turajlic, Samra ;

Hiley, Crispin ;

Lee, Siow Ming ;

Forster, Martin D. ;

Ahmad, Tanya ;

Falzon, Mary ;

Borg, Elaine ;

Lawrence, David ;

Hayward, Martin ;

Kolvekar, Shyam ;

Panagiotopoulos, Nikolaos ;

Janes, Sam M. ;

Thakrar, Ricky ;

Ahmed, Asia ;

Blackhall, Fiona ;

Summers, Yvonne ;

Hafez, Dina ;

Naik, Ashwini .

NATURE, 2017, 545 (7655) :446-+

[2] Assessment of circulating tumor DNA in pediatric solid tumors: The promise of liquid biopsies [J].

Abbou, Samuel D. ;

Shulman, David S. ;

DuBois, Steven G. ;

Crompton, Brian D. .

PEDIATRIC BLOOD & CANCER, 2019, 66 (05)

[3] Donor splice-site mutations in WT1 are responsible for Frasier syndrome [J].

Barbaux, S ;

Niaudet, P ;

Gubler, MC ;

Grunfeld, JP ;

Jaubert, F ;

Kuttenn, F ;

Fekete, CN ;

SouleyreauTherville, N ;

Thibaud, E ;

Fellous, M ;

McElreavey, K .

NATURE GENETICS, 1997, 17 (04) :467-470

[4] ANAPLASTIC WILMS-TUMOR, A SUBTYPE DISPLAYING POOR-PROGNOSIS, HARBORS P53 GENE-MUTATIONS [J].

BARDEESY, N ;

FALKOFF, D ;

PETRUZZI, MJ ;

NOWAK, N ;

ZABEL, B ;

ADAM, M ;

AGUIAR, MC ;

GRUNDY, P ;

SHOWS, T ;

PELLETIER, J .

NATURE GENETICS, 1994, 7 (01) :91-97

[5] ANAPLASTIC WILMS TUMOR - CLINICAL AND PATHOLOGIC-STUDIES [J].

BONADIO, JF ;

STORER, B ;

NORKOOL, P ;

FAREWELL, VT ;

BECKWITH, JB ;

DANGIO, GJ .

JOURNAL OF CLINICAL ONCOLOGY, 1985, 3 (04) :513-520

[6] Characteristics and outcomes of children with the Wilms Tumor-Aniridia syndrome: A report from the National Wilms Tumor Study Group [J].

Breslow, NE ;

Norris, R ;

Norkool, PA ;

Kang, T ;

Beckwith, JB ;

Perlman, EJ ;

Ritchey, ML ;

Green, DM ;

Nichols, KE .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (24) :4579-4585

[7] Relapse of Wilms' tumour and detection methods: a retrospective analysis of the 2001 Renal Tumour Study Group-International Society of Paediatric Oncology Wilms' tumour protocol database [J].

Brok, Jesper ;

Lopez-Yurda, Marta ;

Tinteren, Harm V. ;

Treger, Taryn D. ;

Furtwaengler, Rhoikos ;

Graf, Norbert ;

Bergeron, Christophe ;

van den Heuvel-Eibrink, Marry M. ;

Pritchard-Jones, Kathy ;

Olsen, Oystein E. ;

de Camargo, Beatriz ;

Verschuur, Arnauld ;

Spreafico, Filippo .

LANCET ONCOLOGY, 2018, 19 (08) :1072-1081

[8] Biology and treatment of renal tumours in childhood [J].

Brok, Jesper ;

Treger, Taryn D. ;

Gooskens, Saskia L. ;

van den Heuvel-Eibrink, Marry M. ;

Pritchard-Jones, Kathy .

EUROPEAN JOURNAL OF CANCER, 2016, 68 :179-195

[9] ISOLATION AND CHARACTERIZATION OF A ZINC FINGER POLYPEPTIDE GENE AT THE HUMAN CHROMOSOME-11 WILMS TUMOR LOCUS [J].

CALL, KM ;

GLASER, T ;

ITO, CY ;

BUCKLER, AJ ;

PELLETIER, J ;

HABER, DA ;

ROSE, EA ;

KRAL, A ;

YEGER, H ;

LEWIS, WH ;

JONES, C ;

HOUSMAN, DE .

CELL, 1990, 60 (03) :509-520

[10] Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat [J].

Carrieri, Claudia ;

Cimatti, Laura ;

Biagioli, Marta ;

Beugnet, Anne ;

Zucchelli, Silvia ;

Fedele, Stefania ;

Pesce, Elisa ;

Ferrer, Isidre ;

Collavin, Licio ;

Santoro, Claudio ;

Forrest, Alistair R. R. ;

Carninci, Piero ;

Biffo, Stefano ;

Stupka, Elia ;

Gustincich, Stefano .

NATURE, 2012, 491 (7424) :454-+

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