Synthesis of 2-Chloro-6-(trifluoromethyl)pyridine-3,5-dicarbonitrile: A Versatile Building Block for the Synthesis of Substituted Trifluoro Methyl Pyridine Derivatives

被引：4

作者：

Channapur, Manjunath ^{[1
]}

Hall, Roger G. ^{[2
]}

Kessabi, Jilali ^{[2
]}

Montgomery, Mark G. ^{[3
]}

Shyadligeri, Ashok ^{[1
]}

机构：

[1] Syngenta Biosci Pvt Ltd, Santa Monica Works, Ilhas 403110, Goa, India

[2] Syngenta Crop Protect AG, Schaffhauserstr, CH-4332 Stein, Switzerland

[3] Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

来源：

CHEMISTRYSELECT | 2023年 / 8卷 / 10期

关键词：

electrocyclization; heterocycle; nucleophiles; pyrazolopyridines; trifluoromethylpyridines; EFFICIENT SYNTHESIS; MONO;

D O I：

10.1002/slct.202300390

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and highly efficient (concise 3-step) synthesis of 2-chloro-6-(trifluoromethyl)pyridine-3,5-dicarbonitrile has been developed from readily available starting materials. Furthermore, the selective reactivity of this tetra- substituted pyridine with different carbon, sulfur, nitrogen and oxygen nucleophiles offers great scope for the synthesis of novel highly substituted pyridine derivatives in decent to good yields.

引用

页数：7

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