The role of bixin as antioxidant, anti-inflammatory, anticancer, and skin protecting natural product extracted from Bixa orellana L

被引：14

作者：

Ashraf, Asma ^{[1
]}

Ijaz, Muhammad Umar ^{[2
]}

Muzammil, Saima ^{[3
]}

Nazir, Muhammad Muzammil ^{[1
]}

Zafar, Saima ^{[1
]}

Zihad, S. M. Neamul Kabir ^{[4
,5
]}

Uddin, Shaikh Jamal ^{[5
]}

Hasnain, Md Saquib ^{[6
]}

Nayak, Amit Kumar ^{[7
]}

机构：

[1] Govt Coll Univ, Dept Zool, Faisalabad 38000, Pakistan

[2] Univ Agr Faisalabad, Dept Zool Wildlife & Fisheries, Faisalabad 38040, Pakistan

[3] Govt Coll Univ, Dept Microbiol, Faisalabad 38000, Pakistan

[4] State Univ Bangladesh, Dept Pharm, Dhaka 1205, Bangladesh

[5] Khulna Univ, Pharm Discipline, Khulna 9208, Bangladesh

[6] Palamu Inst Pharm, Dept Pharm, Daltonganj 822102, Jharkhand, India

[7] Siksha O Anusandhan Deemed Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Bhubaneswar 751003, Odisha, India

来源：

FITOTERAPIA | 2023年 / 169卷

关键词：

Bixin; Bixa orellana L; Anticancer; Anti-inflammatory; Antioxidant; LIPID-PEROXIDATION; MEDICINAL-PLANTS; MELANOMA-CELLS; ANNATTO; INFLAMMATION; RECEPTOR; METABOLISM; APOPTOSIS; PIGMENT; PATHWAY;

D O I：

10.1016/j.fitote.2023.105612

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Since long, medicinal plants or herbs are being used in different traditional treatment systems as therapeutic agents to treat a variety of illnesses. Bixa orellana L., an medicinal plant (family: Bixaceae), is an Ayurvedic herb used to treat dyslipidemia, diarrhoea, and hepatitis since ancient times. B. orellana L., seeds contain an orange-red coloured component known as bixin (C25H30O4), which constitutes 80% of the extract.Chemically, bixin is a natural apocarotenoid, biosynthesized through the oxidative degradation of C40 carotenoids. Bixin helps to regulate the Nrf2/MyD88/TLR4 and TGF-1/PPAR-/Smad3 pathways, which further give it antifibrosis, antiox-idant, and anti-inflammatory properties. This current review article presents a comprehensive review of bixin as an anti-inflammatory, antioxidant, anticancer,and skin protecting natural product. In addition, the biosynthesis and molecular target of bixin, along with bixin extraction techniques, are also presented.

引用

页数：8

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