Handheld UV spectrophotometer device for detection of methamphetamine hydrochloride based on supramolecular sensing platform

被引:0
作者
Ran, Xin [1 ]
Yu, Yanbo [1 ]
Yang, Hongxing [1 ]
Tan, Xiaoping [1 ,4 ]
Ran, Zhiyong [3 ]
Zhang, Ruilin [2 ]
Du, Guanben [1 ]
Yang, Long [1 ]
机构
[1] Southwest Forestry Univ, Int Joint Res Ctr Biomass Mat, Yunnan Prov Key Lab Wood Adhes & Glued Prod, Kunming 650224, Peoples R China
[2] Kunming Med Univ, Sch Forens Med, NHC Key Lab Drug Addict Med, Kunming 650500, Peoples R China
[3] Harbin Inst Technol, Sch Med & Hlth, Key Lab Microsyst & Microstruct Mfg, Minist Educ, 92 XiDaZhi St, Harbin 150001, Peoples R China
[4] Yangtze Normal Univ, Coll Chem & Chem Engn, Fuling 408100, Peoples R China
基金
中国国家自然科学基金;
关键词
Amphetamine drugs; Pillar[5]arene; Handheld sensor; Silver nanoparticle; HOST; NANOPARTICLES; RECOGNITION; PROBE;
D O I
10.1016/j.saa.2023.123499
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
The realization of drug detection in drug-using crime sites can provide law enforcement officials with direct evidence. This research has developed and demonstrated an easy-to-use handheld sensor that can quickly detect methamphetamine (MA) in the field. The core of the handheld UV spectrophotometer device (HUVSD) is the STM32F103 series of single-chip micro-controller, which has a 32-bit microcontroller and two embedded 12-bit high-precision analog-to-digital converter (ADC) modules. Through Bluetooth-wireless transmission protocol, the spectral information can be displayed in the cell phone's app, and it is possible to visually determine whether the test sample contains methamphetamine hydrochloride substances based on the characteristic peak at 410 nm. The readily available and inexpensive inducible compound 3A and the phosphate pillar[5]arene@silver nano -particle (PP5@AgNPs) colloidal solution were used as the reactants. The PP5@AgNPs colloidal solution and 3A were mixed and reacted at room temperature, and the color changed to gray-black. The color change was caused by the aggregation of AgNPs induced by the molecular recognition between the induction compound 3A and PP5 on the AgNPs surface. After continuing to add the drug MA, the color of the colloidal solution turned yellow again. This is due to the occurrence of competitive molecular recognition, and the interaction between PP5 and 3A/MA was investigated by molecular docking simulations. The HUVSD has high sensitivity, simple equipment, time-saving, color change visualization and suitable for on-site deployment. It only needs a Pasteur pipette, which has great potential to realize rapid on-site detection.
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页数:9
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