Current Trends in Neoantigen-Based Cancer Vaccines

被引：16

作者：

Ho, Szu-Ying ^{[1
]}

Chang, Che-Mai ^{[1
]}

Liao, Hsin-Ni ^{[1
]}

Chou, Wan-Hsuan ^{[1
]}

Guo, Chin-Lin ^{[2
]}

Yen, Yun ^{[3
,4
,5
]}

Nakamura, Yusuke ^{[6
,7
]}

Chang, Wei-Chiao ^{[1
,8
,9
]}

机构：

[1] Taipei Med Univ, Sch Pharm, Dept Clin Pharm, Taipei 110, Taiwan

[2] Acad Sinica, Inst Phys, Taipei 115, Taiwan

[3] Taipei Med Univ, Coll Med Sci & Technol, PhD Program Canc Mol Biol & Drug Discovery, Taipei 110, Taiwan

[4] Taipei Med Univ, Grad Inst Canc Biol & Drug Discovery, Coll Med Sci & Technol, Taipei 110, Taiwan

[5] Taipei Med Univ, TMU Res Ctr Canc Translat Med, Taipei 110, Taiwan

[6] Japanese Fdn Canc Res, Canc Precis Med Ctr, Tokyo 1358550, Japan

[7] Natl Inst Biomed Innovat Hlth & Nutr, Osaka 5670085, Japan

[8] Taipei Med Univ, Wan Fang Hosp, Integrat Res Ctr Crit Care, Dept Med Educ & Res, Taipei 116, Taiwan

[9] Taipei Med Univ, Wan Fang Hosp, Dept Pharm, Taipei 116, Taiwan

来源：

PHARMACEUTICALS | 2023年 / 16卷 / 03期

关键词：

cancer neoantigen; T-cell response; immune system; neoantigen vaccine; INTRATUMOR HETEROGENEITY; IMMUNE ESCAPE; CELL; THERAPY; IMMUNOTHERAPY; LANDSCAPE; STABILITY; ANTI-PD-1; MELANOMA; TARGETS;

D O I：

10.3390/ph16030392

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cancer immunotherapies are treatments that use drugs or cells to activate patients' own immune systems against cancer cells. Among them, cancer vaccines have recently been rapidly developed. Based on tumor-specific antigens referred to as neoantigens, these vaccines can be in various forms such as messenger (m)RNA and synthetic peptides to activate cytotoxic T cells and act with or without dendritic cells. Growing evidence suggests that neoantigen-based cancer vaccines possess a very promising future, yet the processes of immune recognition and activation to relay identification of a neoantigen through the histocompatibility complex (MHC) and T-cell receptor (TCR) remain unclear. Here, we describe features of neoantigens and the biological process of validating neoantigens, along with a discussion of recent progress in the scientific development and clinical applications of neoantigen-based cancer vaccines.

引用

页数：16

共 67 条

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