Nickel phosphide for MRI-guided synergistic photo-immunotherapy

被引：3
作者：
An, Na [1 ]
Gao, Yan [1 ]
Shi, Ying [2 ]
Du, Xingxing [3 ]
Cheng, Jianing [3 ]
Tang, Shuanglong [1 ]
Liu, Pengfei [2 ]
Yang, Huike [3 ]
Guo, Chongshen [1 ]
机构：
[1] Harbin Inst Technol, Sch Chem & Chem Engn, Harbin 150001, Peoples R China
[2] Harbin Med Univ, Affiliated Hosp 1, Magnet Resonance Dept, Harbin 150001, Peoples R China
[3] Harbin Med Univ, Dept Anat, Harbin 150081, Peoples R China
来源：
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY | 2023年 / 151卷
基金：
美国国家科学基金会;
关键词：
Nickel phosphide; Magnetic resonance imaging; Phototherapy; Immunotherapy; THERAPY; NANOPARTICLES; COMBINATION; SYSTEMS;
D O I：
10.1016/j.jmst.2022.12.032
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Developing a phototherapy modality to ablate tumor and then trigger immunogenic cell death (ICD) for simultaneously eliminating distal and metastatic tumors holds great promise in clinical applications. Herein, the polyethylene glycol functionalized Ni2P (Ni2P@PEG NPs) is developed with enhanced biocom-patibility, high photoabsorption and photothermal efficiency, as well as reactive oxygen species generation ability. Of particular note, Ni2P@PEG NPs mediated phototherapy could not only realize efficient ablation of primary tumors, but also inhibit distal tumors and metastatic tumors by triggering an antitumor im-mune response. The above conclusions were verified by B mode ultrasound, western blot assay, and im-munohistochemistry analysis. Meanwhile, Ni2P@PEG NPs showed excellent magnetic resonance imaging (MRI) properties. In summary, the MRI-guided multimodal cancer therapies of Ni2P@PEG NPs represent significant potential for clinical applications.(c) 2023 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
引用
收藏
页码：150 / 161
页数：12
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