Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors

被引：6

作者：

Diaz, Maria ^{[1
]}

Chudsky, Sofia ^{[2
,3
]}

Pentsova, Elena ^{[4
]}

Miller, Alexandra M. ^{[4
,5
]}

机构：

[1] Columbia Univ, Dept Neurol, Div Neurooncol, Irving Med Ctr, New York, NY USA

[2] Mem Sloan Kettering Canc Ctr, Off Profess Dev, New York, NY USA

[3] Hunter Coll, New York, NY USA

[4] Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY USA

[5] Mem Sloan Kettering Canc Ctr, Dept Neurol, 1275 York Ave, New York, NY 10065 USA

来源：

TRANSLATIONAL ONCOLOGY | 2024年 / 41卷

关键词：

Liquid biopsy; Cerebrospinal fluid; Tumor biomarkers; Circulating tumor cells; Cell -free DNA; Circulating tumor DNA; Brain tumors; BREAST-CANCER PATIENTS; LEPTOMENINGEAL METASTASES; FLOW-CYTOMETRY; PROGNOSTIC-SIGNIFICANCE; RESIDUAL DISEASE; CELLS; DIAGNOSIS; TECHNOLOGY; CSF; DNA;

D O I：

10.1016/j.tranon.2024.101881

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

For patients with central nervous system (CNS) malignancies, liquid biopsies of the cerebrospinal fluid (CSF) may offer an unparalleled source of information about the tumor, with much less risk than traditional biopsies. Two techniques have been adapted to CSF in clinical settings: circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). CTCs have been employed mostly as a diagnostic tool for leptomeningeal metastases in epithelial tumors, although they may also have value in the prognostication and monitoring of this disease. The ctDNA technology has been studied in a variety of primary and metastatic brain and spinal cord tumors, where it can be used for diagnosis and molecular classification, with some work suggesting that it may also be useful for longitudinal tracking of tumor evolution or as a marker of residual disease. This review summarizes recent publications on the use of these two tests in CSF, focusing on their established and potential clinical applications.

引用

页数：7

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