Effect of Statins on Blood Lipids and Oxidative Stress: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Statins intake protects against hyperlipidemia, however randomized controlled trials have shown mixed outcomes. We conducted a literature review and meta -analysis to determine how statin affects blood lipids. Antioxidant Statins supplementation is also widely known. Clinical trials on Statins supplementation and oxidative stress have generated conflicting results. We investigated how Statins consumption affects blood lipids and oxidative stress in adults. Using keywords, PubMed, Scopus, Embase, and ISI Web of Science were searched for English -language publications up to 22 January 2023. Random effect models estimated blood lipid changes between Statins supplementation and control groups using weighted mean differences (WMD) with 95% confidence intervals (CIs). We identified a total of 1444 published studies through a systematic search of databases. Out of these, 134 studies were directly related to the topic of our study. However, after a careful evaluation, 106 studies were excluded based on specific criteria. Statins supplementation demonstrated substantial benefits on TAC (WMD: 0.20 mmol/L; 95% CI: 0.09, 0.32, p < 0.001) and significant heterogeneity between trials (I2 = 98.6%, p < 0.001), which was mostly associated to gender and BMI. TAC subgroup analysis showed a significant connection except for low -dose supplementation and obese people. Meta -regression showed a linear inverse link between dosage and substantial MDA decrease (r = -2117.18,p = 0.017). Our findings showed that Statins lowers LDL cholesterol and TC but not HDL or triglycerides in both normal weight and overweight/obese people, however further well -designed studies with more diverse populations and longer duration are needed. Our findings need longer RCTs.