Molecular biomarkers in prostate cancer tumorigenesis and clinical relevance

被引：2

作者：

Alqualo, Nathalia Oliveira ^{[1
]}

Campos-Fernandez, Esther ^{[1
]}

Picolo, Bianca Uliana ^{[1
]}

Ferreira, Emanuelle Lorrayne ^{[1
]}

Henriques, Laila Machado ^{[1
]}

Lorenti, Sabrina ^{[1
]}

Moreira, Danilo Caixeta ^{[1
]}

Simiao, Maria Paula Silva ^{[1
]}

Oliveira, Luciana Beatriz Tiago ^{[1
]}

Alonso-Goulart, Vivian ^{[1
,2
]}

机构：

[1] Univ Fed Uberlandia, Inst Biotechnol, Lab Nanobiotechnol, Prof Dr Luiz Ricardo Goulart Filho, BR-38400902 Uberlandia, MG, Brazil

[2] Univ Fed Uberlandia, BR-996406010 Uberlandia, Brazil

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2024年 / 194卷

关键词：

Prostate cancer; Molecular markers; CTC; Metastatic cascade; Tumorigenesis; Metastasis; CIRCULATING TUMOR-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; INTERMEDIATE-FILAMENTS; SIGNALING PATHWAY; MESSENGER-RNA; MUTATIONS; ABIRATERONE; AR-V7; EXPRESSION; PROGNOSIS;

D O I：

10.1016/j.critrevonc.2023.104232

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Prostate cancer (PCa) is the second most frequent type of cancer in men and assessing circulating tumor cells (CTCs) by liquid biopsy is a promising tool to help in cancer early detection, staging, risk of recurrence evaluation, treatment prediction and monitoring. Blood-based liquid biopsy approaches enable the enrichment, detection and characterization of CTCs by biomarker analysis. Hence, comprehending the molecular markers, their role on each stage of cancer development and progression is essential to provide information that can help in future implementation of these biomarkers in clinical assistance. In this review, we studied the molecular markers most associated with PCa CTCs to better understand their function on tumorigenesis and metastatic cascade, the methodologies utilized to analyze these biomarkers and their clinical significance, in order to summarize the available information to guide researchers in their investigations, new hypothesis formulation and target choice for the development of new diagnostic and treatment tools.

引用

页数：21

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