Crosstalk between gut microbiota and gut resident macrophages in inflammatory bowel disease

被引：15

作者：

Zhang, Haohao ^{[1
,4
]}

Wang, Xueying ^{[1
]}

Zhang, Jing ^{[1
]}

He, Yixuan ^{[1
]}

Yang, Xiumin ^{[1
]}

Nie, Yongzhan ^{[2
,3
]}

Sun, Lijuan ^{[1
,2
,3
]}

机构：

[1] Northwest Univ, Sch Med, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, 229 Taibai North Rd, Xian 710069, Shaaxi Province, Peoples R China

[2] Fourth Mil Med Univ, Natl Clin Res Ctr Digest Dis, State Key Lab Canc Biol, Xian, Shaaxi Province, Peoples R China

[3] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian, Shaaxi Province, Peoples R China

[4] Guangxi Med Univ, Natl Ctr Int Res Biotargeting Theranost, Collaborat Innovat Ctr Targeting Tumor Diag & Ther, State Key Lab Targeting Oncol,Guangxi Key Lab Biot, Nanning, Guangxi, Peoples R China

来源：

JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE | 2023年 / 11卷 / 04期

基金：

中国国家自然科学基金;

关键词：

gut microbiota; macrophage; inflammatory bowel disease; bacterial metabolite; in-nate immunity; INTESTINAL MACROPHAGES; RECEPTOR; COLITIS; MICE;

D O I：

10.2478/jtim-2023-0123

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Macrophages residing in the gut maintain gut homeostasis by orchestrating patho-gens and innocuous antigens. A disturbance in macrophages leads to gut inflamma-tion, causing conditions such as inflammatory bowel disease (IBD). Macrophages ex-hibit remarkable plasticity, as they are sensitive to various signals in the tissue micro-environment. During the recent decades, gut microbiota has been highlighted refer-ring to their critical roles in immunity response. Microbiome-derived metabolites and products can interact with macrophages to participate in the progression of IBD. In this review, we describe recent findings in this field and provide an overview of the current understanding of microbiota-macrophages interactions in IBD, which may lead to the development of new targets and treatment options for patients with IBD.

引用

页码：382 / 392

页数：11

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