Protective effects of tanshinone IIA on sepsis-induced multiple organ dysfunction: a literature review

被引：0

作者：

Lili, Wang ^{[1
,2
]}

Ju, Feng ^{[1
,2
]}

Daqian, Zhan ^{[1
,2
]}

Junshuai, Wang ^{[1
,2
]}

Daixing, Zhou ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Emergency Dept, Wuhan 430030, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Intens Care Unit, Wuhan 430030, Peoples R China

来源：

JOURNAL OF TRADITIONAL CHINESE MEDICINE | 2023年 / 43卷 / 05期

关键词：

tanshinoneIIA; sepsis; multiple organ failure; review; DISSEMINATED INTRAVASCULAR COAGULATION; ATTENUATES CARDIAC DYSFUNCTION; ACUTE KIDNEY INJURY; ACUTE LUNG INJURY; MICROCIRCULATORY DISTURBANCE; SMALL-INTESTINE; SEPTIC SHOCK; SULFONATE; INFLAMMATION; MICE;

D O I：

10.19852/j.cnki.jtcm.20230727.003

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Tanshinone II A (Tan II A) is a noteworthy lipophilic diterpene compound derived from the dried roots of the Traditional Chinese Medicine Danshen (Radix Salviae Miltiorrhizae) that has various pharmacological properties, including anti-inflammatory, antibacterial, and antioxidative effects. Sepsis is a life-threatening organ dysfunction induced by a dysregulated host response to infection. Recently, increasing attention has been paid to sepsis-induced dysfunction of the intestine, cardiovascular system, lungs, kidneys, liver, and other organs. Experimental studies have shown that Tan II A has therapeutic potential for sepsis-induced organ dysfunction owing to its anti-inflammatory, anti-apoptotic and regulatory effects on multiple signalling pathways. The purpose of this article is to evaluate the potential multiorgan protective effects of TanIIA in sepsis.(c) 2023 JTCM. All rights reserved.

引用

页码：1040 / 1046

页数：7

共 81 条

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